COMMENT
Two exponents synapse.
Written by Oz Kahana 23.4.99
risetime = time to peak
tfast = tau fast
tslow = tau slow
gmax = amp
g = gmax*(-Ar*exp(-t/rt) + Af*exp(-t/tf) + As*exp(-t/ts))
according to Galarreta and Hastrin - J.Neurosci., October 1, 1997, 17(7220-7227)
Af = 76%
As = 24%
Ar = 100%
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
POINT_PROCESS two_exp_syn1
RANGE Ar, Af, As, onset, risetime, tslow, tfast, gmax, e, i, g
NONSPECIFIC_CURRENT i
}
UNITS {
(nA) = (nanoamp)
(mV) = (millivolt)
(umho) = (micromho)
}
PARAMETER {
onset = 0 (ms)
risetime = 0.5
tfast = 7.5 (ms)
tslow = 33
gmax = 0.01 (umho)
e = 0 (mV)
v (mV)
Af = 0.76
Ar = 1.00
As = 0.24
cst
T
}
INITIAL {
T = -log(Af*risetime/(Ar*tfast))/(1/risetime - 1/tfast)
cst = 1/(Af*exp(-T/tfast)-Ar*exp(-T/risetime)+(As*exp(-T/tslow)))
}
ASSIGNED { i (nA) g (umho)}
BREAKPOINT {
g = get_g()
i = g*(v - e)
}
FUNCTION get_g() {
if ((t>onset) && ((((t-onset)/risetime)<10) && (((t-onset)/tfast)<10) && (((t-onset)/tslow)<10))) {
get_g = gmax*cst*(-Ar*exp(-(t-onset)/risetime) + Af*exp(-(t-onset)/tfast) + As*exp(-(t-onset)/tslow))
}
else
{
get_g = 0
}
}