GF input TNF input TNFR1 TRADD TRAF FADD RIP cFLIP Cas8 TNFR2 TRAF2 NIK IKK IkB NFkB A20 MEKK1 JNKK JNK Cas7 Cas12 Cas9 APC Cas3 Cas6 BID BcIX BAD p53 Apaf1 PTEN Mito IAP GFR PI3K PIP2 PIP3 Akt Mdm2 DNADamage 2 Apoptosis 20