// Define simulation defaults that may need to be changed for optimization but // that will be the same for all morphologies and for both spiking and // non-spiking models. //Sodium channel kinetics & voltage dependence float Vhalfm_NaF = -0.0324 float Km_NaF = 0.005 float taummax_NaF = 0.000028 float taummin_NaF = 0.000028 float V0h_NaF = -0.048 float Kh_NaF = -0.0028 float tauhV0_NaF = -0.043 float tauhmax_NaF = 0.004 float tauhmin_NaF = 0.00025 // 0.0002 float V0s_NaF = -0.040 float Ks_NaF = -0.0054 float mins_NaF = 0.15 float Ktaus1_NaF = 0.0183 float Ktaus2_NaF = 0.010 float tausmax_NaF = 1 float tausmin_NaF = 0.01 float Vhalfm_NaP = -0.050 float V0h_NaP = -0.057 float Kh_NaP = -0.004 float hmin_NaP = 0.154 float V0s_NaP = -0.01 float Abeta_NaP = 6.94 float Bbeta_NaP = 0.447 //Kv2 properties float npower_Kv2 = 4 float Vhalfn_Kv2 = -0.018 float Kn_Kv2 = 0.0091 float taunmax_Kv2 = 0.03 float taunmin_Kv2 = 0.0001 float hmin_Kv2 = 0.2 //Kv3 properties float npower_Kv3 = 4 float Vhalfn_Kv3 = -0.013 // Actual Vhalf float Kn_Kv3 = 0.0078 // Yields K = 6 mV with Xpower = 4 float hmin_Kv3 = 0.6 //Kv4 properties float V0n_Kv4 = -0.049 // Yields Vhalf = -27 mV when Xpower = 4 float Kn_Kv4 = 0.0125 // Yields K = 9.6 mV when Xpower = 4 float Ktaun1_Kv4 = 0.029 float Ktaun2_Kv4 = 0.029 float V0h_Kv4 = -0.083 // changed from -0.072 02/17/2005 to match // Tkatch et al float Kh_Kv4 = -0.01 // changed from -0.0047 02/17/2005 to match // Tkatch et al float Ktauh1_Kv4 = 0.010 float Ktauh2_Kv4 = 0.010 //KCNQ properties float Vhalfn_KCNQ = -0.0285 float Kn_KCNQ = 0.0195 // Yields K = 15 mV for 1st order Boltzmann // when Xpower = 4. //SK channel properties float EC50_SK = 0.00035 // SI unit = mM; default = 350 nM. float dQ10_SK = 2 //CaHVA properties float npower_CaHVA = 1 float Vhalfn_CaHVA = -0.02 float Kn_CaHVA = 0.007 //Voltage-gated ion channel reversal potentials float ENa = 0.050 float ECa = 0.130 float EK = -0.090 float Eh = -0.03 //Calcium concentration parameters float B_Ca_GP_conc = 4.0/3.0*5.2e-12//3.6e-7// float shell_thick = 20e-9 // meters float tau_CaClearance = 0.001 // time constant for Ca2+ clearance (sec) //Synaptic conductances // STN excitatory inputs float G_AMPA = 0.25e-9//0.25e-9 float tauRise_AMPA = 0.001 float tauFall_AMPA = 0.003 float G_NMDA = {G_AMPA} //not used yet! float tauRise_NMDA = 0.01 float tauFall_NMDA = 0.03 // Striatal inhibitory inputs float G_GABA = 0.25e-9 float tauRise_GABA = 0.001 float tauFall_GABA = 0.012 // Pallidal inhibitory collaterals float G_GABA_GP = 1.50e-9 //pallidal inputs float tauRise_GABA_GP = 0.001 float tauFall_GABA_GP = 0.012 // Default input rates = 0 float STN_rate = 0 float striatum_rate = 0 float pallidum_rate = 0 // Reversal potentials float E_AMPA = 0 float E_NMDA = 0 float E_GABA = -0.080 //simulation defaults str cellpath = "/GP" float dt = 1e-5 float rundur = 3 // duration of each run (seconds)