TITLE HH na channel
: Mel-modified Hodgkin - Huxley conductances (after Ojvind et al.)
: Updated by K. Archie:
: removed leak current
: changed to derivatives rather than explicit step calculation to
: support NEURON's spiffy, smarter integration
: BFB Cleaned (2007)
NEURON {
SUFFIX hh3na
USEION na READ ena WRITE ina
RANGE gbar, g
GLOBAL vmin, vmax
GLOBAL taum, tauh, taus, tausvh, tausvs, tausb
GLOBAL powm, powh, pows
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
gbar = .20 (mho/cm2)
vmin = -120 (mV)
vmax = 100 (mV)
ena (mV)
tausvh = 30 (mV)
tausvs = 1 (mV)
taus = 50 (ms)
tausb = .5 (ms)
taum = .05 (ms)
tauh = .5 (ms)
pows = 0
powm = 2
powh = 1
}
STATE {
h <1e-1>
m <1e-1>
s <1e-1>
}
ASSIGNED {
ina (mA/cm2)
g (mho/cm2)
}
INITIAL {
m = ssm(v)
h = ssh(v)
s = sss(v)
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gbar*(m^powm)*(h^powh)*(s^pows)
ina = g*(v - ena)
}
DERIVATIVE states {
m' = (ssm(v) - m)/taum
h' = (ssh(v) - h)/tauh
s' = (sss(v) - s)/tauss(v)
}
FUNCTION ssm(v (mV)) { : Na activation steady state
TABLE FROM vmin TO vmax WITH 200
ssm = 1/(1 + exp((v + 40 (mV))/-3 (mV)))
}
FUNCTION ssh(v (mV)) { : Na inactivation steady state
TABLE FROM vmin TO vmax WITH 200
ssh = 1/(1 + exp((v + 45 (mV))/3 (mV)))
}
FUNCTION sss(v (mV)) { : Na ... steady state
TABLE FROM vmin TO vmax WITH 200
sss = 1/(1 + exp((v + 44 (mV))/3 (mV)))
}
FUNCTION tauss(v (mV)) (ms) { : Na ... tau
TABLE FROM vmin TO vmax WITH 200
tauss = tausb + taus/(1 + exp((v + tausvh)/tausvs))
}