TITLE HVA (L-type) calcium channel with low threshold for activation (dendrites)
COMMENT
Used in distal dendrites to account for distally restricted initiation of Ca++ spikes.
Uses channel conductance (not permeability).
Written by Yiota Poirazi, 1/8/00 poirazi@LNC.usc.edu.
ENDCOMMENT
NEURON {
SUFFIX calH
USEION ca READ eca WRITE ica
RANGE gcalbar, ica
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
}
PARAMETER { :parameters that can be entered when function is called in cell-setup
gcalbar = 0 (S/cm2) : initialized conductance
}
ASSIGNED { :parameters needed to solve DE
v (mV)
celsius (degC)
ica (mA/cm2)
eca (mV) : Ca2+ reversal potential
minf (1)
hinf (1)
taum (ms)
tauh (ms)
}
STATE { :unknown activation and inactivation parameters to be solved in the DEs
m
h
}
BREAKPOINT {
SOLVE states METHOD cnexp
ica = gcalbar*pow(m, 3)*h*(v - eca)
}
DERIVATIVE states {
rates (v)
m' = (minf-m)/taum
h' = (hinf-h)/tauh
}
INITIAL {
rates(v)
m = minf :initial activation parameter value
h = hinf :initial inactivation parameter value
}
PROCEDURE rates(v (mV)) {
minf = 1 / (1 + exp(-(v+37(mV))/1(mV))) :Ca activation
taum = 3.6
hinf = 1 / (1 + exp((v+41(mV))/0.5(mV))) :Ca inactivation
tauh = 29
}