TITLE hyperpolarization-activated channel - h current
COMMENT
Used in Pyramidal Cells.
Based on Magee, 1988, J Neurosci, 18:7613-7624, doi: 10.1523/JNEUROSCI.18-19-07613.1998
ENDCOMMENT
NEURON {
SUFFIX h
NONSPECIFIC_CURRENT ih
RANGE ghbar, vhalf, eh, ih
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
}
PARAMETER {: parameters that can be entered when function is called in cell-setup
ghbar = 0.0 (S/cm2) : initialize conductance to zero
eh = -10 (mV)
K = 3.5 (mV)
vhalf = -90 (mV) : half potential
}
ASSIGNED {: parameters needed to solve DE
v (mV)
ih (mA/cm2)
ninf
taun (ms)
}
STATE {: the unknown parameters to be solved in the DEs
n
}
BREAKPOINT {
SOLVE states METHOD cnexp
ih = ghbar*n*(v-eh)
}
DERIVATIVE states {
rates(v)
n' = (ninf - n)/taun
}
INITIAL {: initialize the following parameter using states()
rates(v)
n = ninf
}
PROCEDURE rates(v (mV)) {
if (v > -30) {
taun = 1
} else {
taun = 2(ms)*(1/(exp(-(v+145(mV))/17.5(mV)) + exp((v+16.8(mV))/16.5(mV))) + 10) :h activation tau
}
ninf = (1 / (1 + exp((v - vhalf)/K))) :steady state value
}