TITLE HVAm (R-type) calcium (CA2+) channel with medium threshold for activation
COMMENT
Used in somatic regions.
It has lower threshold for activation/inactivation and slower activation time constant,
than the same mechanism in dendritic regions.
Uses channel conductance (not permeability).
Written by Yiota Poirazi on 3/12/01 poirazi@LNC.usc.edu.
ENDCOMMENT
NEURON {
SUFFIX somacar
USEION ca READ eca WRITE ica
RANGE gcabar, ica
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
}
PARAMETER { : parameters that can be entered when function is called in cell-setup
gcabar = 0 (S/cm2) : initialized conductance
}
STATE { : unknown activation and inactivation parameters to be solved in the DEs
m
h
}
ASSIGNED { : parameters needed to solve DE
v (mV)
eca (mV) : Ca2+ reversal potential
ica (mA/cm2)
minf (1)
hinf (1)
taum (ms)
tauh (ms)
}
BREAKPOINT {
SOLVE states METHOD cnexp
ica = gcabar*pow(m, 3)*h*(v - eca)
}
DERIVATIVE states {
rates(v)
m' = (minf - m)/taum
h' = (hinf - h)/tauh
}
INITIAL {
rates(v)
m = 0 : initial activation parameter value
h = 1 : initial inactivation parameter value
}
PROCEDURE rates(v (mV)) {
minf = 1 / (1 + exp((v + 55(mV))/(-3(mV)))) :Ca activation
hinf = 1 / (1 + exp((v + 57(mV))/(1(mV)))) :Ca inactivation
taum = 100.0
tauh = 5.0
}