// For each band of AMPA and NMDA synapses, this function makes a file with
// the stimulation train and shifts the activation time (by temporal_offset)
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu
double iaryE[1000]
objref varyE[1000], s_file, stimtmp, rpid, shiftsynf
stimtmp=new Vector()
strdef shiftsyn_filename, syscmd, estr, shiftsyns
proc shiftsyn_init () { local synapses, temporal_offset, hertz, gmax_default, PID, lo, hi
total_synapses = $1 // number of synapses in the band
tstop = $2 // stimulation end time
dt = $3
hertz = $4 // stimulation train frequency
synch = $5 // synchronous or a synchronous stimulation of synapses
perio = $6 // periodic or not periodic stimulation
PID = $7
PID = abs(PID) // only positive random seeds used for spike train generation
temporal_offset = $8 // shift stimulation time by temporal_offset
skip = $9 // time points to skip before starting the spike train
items = int(tstop/dt) // number of stimuli (firing patterns) for each synapse
// Make the desired activation pattern file and
// Set AMPA and NMDA pointers to activation pattern
if (hertz > 3) { // in most cases
sprint(shiftsyn_filename,"shiftsyn-%d-%.2f-%.2f-%.2f-%.2f-%.2f-%d-%.2f",\
total_synapses,tstop,dt,hertz,synch,perio,PID,temporal_offset) // filename
sprint(syscmd,"newshiftsyn shiftsyn %d %g %g %g %g %g %d %g",\
total_synapses,tstop,dt,hertz,synch,perio,PID,temporal_offset) // use newshiftsyn to make
// stimulation train
system(syscmd) // Same as typing syscmd in DOS, execute above command
print syscmd
s_file = new File()
s_file.ropen(shiftsyn_filename) // open the stimulation train file
stimtmp.scanf(s_file) //read temporal stimulation pattern in a 1-d vector
s_file.close()
} else {
// for single shock experiments, set the single spike at t = 0+offset (synchronous stimulation for all synapses)
stimtmp = new Vector(items*total_synapses,0)
offset = temporal_offset/dt
for i = 0, total_synapses-1 {
stimtmp.x[total_synapses*offset + i] = 1
}
}
for i=0,total_synapses-1 {
// printf(" -- synapse %d\n", i)
varyE[i] = new Vector(items) // for each synapse, save firing pattern in this vector
// Put the firing patterns from stimtmp (1-d vector) for each syanpse i
for j=0,items-1 {
varyE[i].x[j]=stimtmp.x[i + j*total_synapses]
}
}
// print "setpointer to each synapse"
for s=0, total_synapses-1 {
sprint(estr,"varyE[%d].play(&iaryE[%d], dt)", s,s)
execute1(estr)
// print estr
sprint(estr,"setpointer ampa[%d].pre, iaryE[%d]", s+skip,s)
execute1(estr)
// print estr
sprint(estr,"setpointer nmda[%d].pre, iaryE[%d]", s+skip,s)
execute1(estr)
print estr
}
if (hertz >3) {
sprint(econ.syscmd, "rm %s", shiftsyn_filename) // remove firing pattern file
print econ.syscmd
system(econ.syscmd)
}
}