COMMENT
Forti etal's (1997) AMPA synapse with two decay time constants based on the
exp2syn.mod mechanism from the NEURON distribution
The value of 0.002 for the fraction of Ca flowing at low membrane
potentials is derived from the measurements of Spruston &al (1995)
Forti & al. 1997 "Loose-patch recordings of single quanta at
individual hippocampal synapses" Nature 388, 874-878
Spruston & al. 1995 "Dendritic glutamate receptor channels in rat
hippocampal CA3 and CA1 neurons" J. Physiol. 482, 325-352
ENDCOMMENT
NEURON {
POINT_PROCESS AmpaSyn
RANGE e, g, i, ica
NONSPECIFIC_CURRENT i
USEION ca READ cai,cao WRITE ica
GLOBAL total, taurise, taufast, tauslow, taurise_exp, taufast_exp, tauslow_exp, afast, aslow, normfac, T_exp, fracca
}
INCLUDE "units.inc"
PARAMETER {
taurise_exp =.2 (ms) <1e-9,1e9> : rise
taufast_exp = 0.61 (ms) <1e-9,1e9> : fast decay
tauslow_exp = 2.55 (ms) <1e-9,1e9> : slow decay
afast = 0.75 <0,1>
e=0 (mV)
fracca= 0.002 : fraction of current that is ca ions
z = 2
celsius = 22 (degC)
T_exp = 22 (degC)
q10 = 3
}
ASSIGNED {
v (mV)
i (nA)
ica (nA)
g (uS)
aslow
total (uS)
cai (mM)
cao (mM)
taurise (ms)
taufast (ms)
tauslow (ms)
normfac
}
BREAKPOINT {
SOLVE state METHOD cnexp
g = (B + C - A)
i = g * (1-fracca) * (v - e)
ica = g * fracca * ghkg(v,cai,cao,z)
}
INCLUDE "triexpsyn.inc"
INCLUDE "ghk.inc"