if (name_declared("pkgversions") != 4 ) { execute("strdef pkgversions") }
sprint(pkgversions,"%sbpap-pars = $Revision: 1.1 $, ",pkgversions)
//
// Parameters
//
objref parlist // Parameter List
proc pars_set_defaults() {
parlist = new VarList()
// Simulation parameters
parlist.appendSetDouble("tstop", 100)
parlist.appendSetDouble("Dt", 0.2) // Time step for recording membrane potentials
parlist.appendSetDouble("dt", dt) // Time step for recording membrane potentials
parlist.appendSetDouble("nruns", 1)
parlist.appendSetDouble("epsp_start", 50)// EPSP start time
// Neuron parameters
parlist.appendSetString("cell_model", "ca1_poirazi")
parlist.appendSetDouble("cell_Ra", 50, "cell_set_cell_pars()", "Ohm-cm")
parlist.appendSetDouble("diam_thresh", 1.5, "", "um") // What counts as a thin branch
// Somatic current injection stimuli
parlist.appendSetDouble("soma_iclamp_amp", 3 , "stim.amp = soma_iclamp_state*soma_iclamp_amp", "nA")
parlist.appendSetDouble("soma_iclamp_del", 50, "stim.del = soma_iclamp_del", "ms")
parlist.appendSetDouble("soma_iclamp_dur", 1, "stim.dur = soma_iclamp_dur", "ms")
parlist.appendSetDouble("soma_iclamp_state", 0, "stim.amp = soma_iclamp_state*soma_iclamp_amp")
// Synapse parameters
parlist.appendSetDouble("nsyn", 250)
// sah.mark_synapses(scall_inputs, screc_inputs)
parlist.appendSetDouble("thickproxfrac", 0.000 )
parlist.appendSetDouble("thickmedfrac", 0.016)
parlist.appendSetDouble("thickdistfrac", 0.129)
parlist.appendSetDouble("thinfrac", 0.855)
// Synaptic Stimuli parameters
parlist.appendSetDouble("noise", 0)
parlist.appendSetDouble("start", 50, "set_all_input_pars()", "ms")
parlist.appendSetDouble("jitter_type", 1, "", "")
parlist.appendSetDouble("jitter", 1, "", "ms")
parlist.appendSetDouble("interval", 500, "set_all_input_pars()", "ms")
parlist.appendSetDouble("spiketime_state",0)
parlist.appendSetString("scstim_file","./scstim.dat")
// Spines and calcium
// 10 R-type ca channels with conductance 16pS; divide by area of spine.
parlist.appendSetDouble("headdiam",0.4,"set_all_input_pars()", "um")
parlist.appendSetDouble("headL",0.2,"set_all_input_pars()", "um")
parlist.appendSetDouble("neckdiam",0.2)
parlist.appendSetDouble("neckL",1)
parlist.appendSetDouble("cai0", 70e-6, "set_all_input_pars()", "mM") // From Sabatini & al (2002)
parlist.appendSetDouble("kappa", 20, "set_all_input_pars()") // From Sabatini & al (2002)
parlist.appendSetDouble("tauca",12, "set_all_input_pars()", "ms") // From Sabatini & al (2002)
// R-type Ca channels on spines
// parlist.appendSetDouble("gmax_car_spine",10*16e-12/(PI*0.2*1.0*1e-8),"set_all_input_pars()","S/cm2")
parlist.appendSetDouble("gmax_car_spine",170,"set_all_input_pars()","pS")
// Synpse paramters
// AMPA
parlist.appendSetDouble("taurise_exp_AmpaSyn", 0.2)
parlist.appendSetDouble("taufast_exp_AmpaSyn", 4)
parlist.appendSetDouble("tauslow_exp_AmpaSyn", 10) // Anything >5 will do
parlist.appendSetDouble("afast_AmpaSyn", 1)
parlist.appendSetDouble("T_exp_AmpaSyn", 33)
parlist.appendSetDouble("e_ampa", 0, "", "mV")
// 0.000022 below thresh; 0.000023 above with cvode and atol=0.001
// And with 0.25ms fixed time step
parlist.appendSetDouble("gsbar_ampa", 0.20E-3, "set_all_input_pars()","uS")
parlist.appendSetDouble("ampa_scaled",0,"set_all_input_pars()")
// NMDA
parlist.appendSetDouble("e_nmda", 0)
parlist.appendSetDouble("gsbar_nmda", 0.045E-3, "set_all_input_pars()","uS")
parlist.appendSetDouble("dendburst_state", 1, "set_all_input_pars()")
parlist.appendSetDouble("ka_blocked_state", 0, "kapblocker.block(ka_blocked_state) kadblocker.block(ka_blocked_state) ")
parlist.appendSetDouble("taulmin_ka",lmin_kad, "lmin_kad=taulmin_ka lmin_kap=taulmin_ka", "ms")
parlist.appendDouble("K0_NmdaSyn", "", "mM")
parlist.appendDouble("delta_NmdaSyn")
parlist.appendDouble("cvode_atol")
parlist.appendDouble("cvode_on")
parlist.appendDouble("dt")
// Set the Vargas & Robinson "Figure 3" parameters
K0_NmdaSyn = 2.57
delta_NmdaSyn = 0.96
}