TITLE H-current that uses Na ions
NEURON {
SUFFIX h
RANGE gbar,vhalf, K, taun, ninf, g, gmax
USEION na WRITE ina
: NONSPECIFIC_CURRENT i
}
UNITS {
(um) = (micrometer)
(mA) = (milliamp)
(uA) = (microamp)
(mV) = (millivolt)
(pmho) = (picomho)
(mmho) = (millimho)
}
PARAMETER { : parameters that can be entered when function is called in cell-setup
v (mV)
eh = -10 (mV)
K = 8.5 (mV)
gbar = 0 (mho/cm2) : initialize conductance to zero
vhalf = -90 (mV) : half potential
}
STATE { : the unknown parameters to be solved in the DEs
n
}
ASSIGNED { : parameters needed to solve DE
ina (mA/cm2)
ninf
taun (ms)
g (mho/cm2)
gmax (mho/cm2)
}
INITIAL { : initialize the following parameter using states()
states(v)
n = ninf
g = gbar*n
ina = g*(v-eh)
gmax = g
}
BREAKPOINT {
SOLVE h METHOD cnexp
g = gbar*n
ina = g*(v-eh)
if (g > gmax) {
gmax = g
}
}
DERIVATIVE h {
states(v)
n' = (ninf - n)/taun
}
PROCEDURE states(v(mV)) {
if (v > -30) {
taun = 1
} else {
taun = 2(ms)*(1/(exp((v+145(mV))/-17.5(mV))+exp((v+16.8(mV))/16.5(mV))) + 5) :h activation tau
}
ninf = 1 - (1 / (1 + exp((vhalf - v)/K))) :steady state value
}