TITLE I-h channel from Magee 1998 for distal dendrites
: with tapering and 2-exp to model currents in CA3, M.Migliore Dec.2005
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
ehd (mV)
celsius (degC)
ghdbar=.0001 (mho/cm2)
vhalfl=-82 (mV)
kl=-7.8
vhalft=-65 (mV)
a0t=0.012 (/ms)
zetat=8 (1)
gmt=.15 (1)
q10=4.5
qtl=1
b0=20
vc=-70
kc=-3
as=0.79
vhalfts=-65 (mV)
a0ts=0.0019 (/ms)
zetats=8 (1)
gmts=.18 (1)
b0s=140
}
NEURON {
SUFFIX hd
NONSPECIFIC_CURRENT i
RANGE ghdbar
GLOBAL linf,taul, tauls
}
STATE {
l
ls
}
ASSIGNED {
i (mA/cm2)
linf
taul
tauls
ghd
}
INITIAL {
rate(v)
l=linf
ls=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ghd = ghdbar*(ls*as+l*(1-as))
i = ghd*(v-ehd)
}
FUNCTION alpt(v(mV)) {
alpt = exp(0.0378*zetat*(v-vhalft))
}
FUNCTION bett(v(mV)) {
bett = exp(0.0378*zetat*gmt*(v-vhalft))
}
FUNCTION alpts(v(mV)) {
alpts = exp(0.0378*zetats*(v-vhalfts))
}
FUNCTION betts(v(mV)) {
betts = exp(0.0378*zetats*gmts*(v-vhalfts))
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rate(v)
l' = (linf - l)/taul
ls' = (linf - ls)/tauls
}
PROCEDURE rate(v (mV)) { :callable from hoc
LOCAL a,qt
: qt=q10^((celsius-33)/10)
linf = (1/(1 + exp(-(v-vhalfl)/kl)))
a = alpt(v)
taul = b0 + bett(v)/(a0t*(1+a))
a = alpts(v)
tauls = b0s + betts(v)/(a0ts*(1+a))
}