:Migliore file Modify by Maciej Lazarewicz (mailto:mlazarew@gmu.edu) May/16/2001
TITLE Borg-Graham K-M channel
NEURON {
SUFFIX KmM95
USEION k READ ek WRITE ik
RANGE gbar,ik
GLOBAL inf,tau
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(mM) = (milli/liter)
}
PARAMETER {
cai (mM)
v (mV)
ek (mV)
celsius = 30 (degC)
gbar = .003 (mho/cm2)
vhalf = -55 (mV)
a0 = 0.006 (/ms)
zeta = -10 (1)
gm = 0.06 (1)
st = 1
}
STATE { m }
ASSIGNED {
ik (mA/cm2)
inf
tau
}
BREAKPOINT {
SOLVE state METHOD cnexp
ik = gbar*m^st*(v-ek)
}
INITIAL {
rate(v)
m=inf
}
FUNCTION alp(v(mV)) {
alp = exp( 1.e-3*zeta*(v-vhalf)*9.648e4/(8.315*(273.16+celsius)))
}
FUNCTION bet(v(mV)) {
bet = exp(1.e-3*zeta*gm*(v-vhalf)*9.648e4/(8.315*(273.16+celsius)))
}
DERIVATIVE state {
rate(v)
m' = (inf - m)/tau
}
PROCEDURE rate(v (mV)) { :callable from hoc
LOCAL a,q10
q10 = 5^((celsius-23)/10)
a = alp(v)
inf = 1/(1 + a)
tau = bet(v)/(q10*a0*(1+a))
}