TITLE Ih CA3
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
NEURON {
SUFFIX hcurrent
NONSPECIFIC_CURRENT ih
RANGE gbar, g, e, v50, htau, hinf
RANGE gfactor, htaufactor
}
PARAMETER {
celsius (degC)
gbar= 0.0001 (mho/cm2)
e= -30 (mV)
v50=-82 (mV)
gfactor = 1
htaufactor = 1
}
STATE {
h
}
ASSIGNED {
ih (mA/cm2)
hinf
htau (ms)
v (mV)
g (mho/cm2)
}
PROCEDURE giassign () {
: ih=g*h*(v-e)*gfactor
g = gbar*h*gfactor
ih = g*(v-e)
}
BREAKPOINT {
SOLVE states METHOD cnexp
giassign()
}
DERIVATIVE states {
rates(v)
h'= (hinf- h)/ htau
}
INITIAL {
rates(v)
h = hinf
giassign()
}
PROCEDURE rates(v (mV)) {
UNITSOFF
: HCN1
:hinf = 1/(1+exp(0.151*(v-v50)))
:htau = exp((0.033*(v+75)))/(0.011*(1+exp(0.083*(v+75))))
: HCN2
hinf = 1/(1+exp((v-v50)/10.5))
htau = htaufactor/(exp(-14.59-0.086*v)+exp(-1.87+0.0701*v))
UNITSON
}