TITLE LEAK
UNITS {
(pA) = (picoamp)
(molar) = (1/liter)
(mV) = (millivolt)
(uS) = (micromho)
(mA) = (milliamp)
(mM) = (millimolar)
F = (faraday) (coulomb)
R = (mole k) (mV-coulomb/degC)
}
INDEPENDENT {v FROM -100 TO 50 WITH 50 (mV)}
NEURON {
SUFFIX leak
USEION ca WRITE ica
USEION na READ nai,ena WRITE ina
USEION k WRITE ik
USEION cl WRITE icl VALENCE 1
RANGE ileak,ina,ica,ik,gnabar,gkbar,nai,nainit,ggabaa
}
PARAMETER {
dt (ms)
gcabar = 0.0 (uS/cm2)
gnabar = 16.3 (uS/cm2)
gkbar = 83.7 (uS/cm2)
ggabaa = 0.0 (uS/cm2)
eca = 20 (mV)
ecl = -65 (mV)
ek = -100 (mV)
ena (mV)
nao = 145 (mM)
nai (mM)
nainit = 4 (mM)
celsius = 35 (degC)
}
ASSIGNED {
ica (mA/cm2)
ina (mA/cm2)
ik (mA/cm2)
icl (mA/cm2)
ileak (mA/cm2)
}
BREAKPOINT {
ena = R*(celsius+273.15)/F*log(nao/nai)
ica = (0.000001)*gcabar*(v-eca)
ina = (0.000001)*gnabar*(v-ena)
icl = (0.000001)*ggabaa*(v-ecl)
ik = (0.000001)*gkbar*(v-ek)
ileak= ica + ina + ik
}
COMMENT
INITIAL{
nai = nainit
ena = R*(celsius+273.15)/F*log(nao/nai)}
ENDCOMMENT