TITLE sodium potassium pump
: from Lindblad et al Am J Physiol 1996 275:H1666
NEURON {
SUFFIX NaKpump
USEION k READ ko, ki WRITE ik
USEION na READ nao, nai WRITE ina
RANGE ik, ina , INaKmax, ink, Kmko, Kmnai
GLOBAL dummy : prevent vectorization for use with CVODE
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
INaKmax = 2.18660e-3 (mA/cm2) <0,1e6>
Kmnai = 10 (mM) <0,1e6>
Kmko = 1.5 (mM) <0,1e6>
}
ASSIGNED {
celsius (degC)
v (mV)
ik (mA/cm2)
ina (mA/cm2)
ko (mM)
ki (mM)
nao (mM)
nai (mM)
ink (mA/cm2)
dummy
}
BREAKPOINT { LOCAL q10 , fnk
q10 = 3^((celsius - 37)/10 (degC))
fnk = (v + 150)/(v + 200)
ink= q10*INaKmax*fnk/((1 + (Kmnai/nai)^1.5)*(1 + Kmko/ko))
ina = 3*ink
ik = -2*ink
}