COMMENT
This is a model for a single input pulse of NMDA type. The conductance of
synaptic input is affected by extracellular Magnesium concentration.
ENDCOMMENT
NEURON {
POINT_PROCESS GluSyn
RANGE erev, g, i, onset
RANGE tp, gmaxampa
RANGE tau1, tau2, gmaxnmda
NONSPECIFIC_CURRENT i
}
UNITS {
(mV) = (millivolt)
(mA) = (milliampere)
(nA) = (nanoampere)
(uS) = (microsiemens)
(umho) = (micromho)
(mM) = (milli / litre)
}
PARAMETER {
v (mV)
onset = 40 (ms)
tp = 1.5 (ms)
gmaxampa = 0.5 (uS)
tau1 = 80 (ms)
tau2 = 0.67 (ms)
gmaxnmda = 0.2 (uS)
erev = 0 (mV)
}
ASSIGNED {
i (nA)
g (uS)
}
INITIAL {
UNITSOFF
syncon(v)
UNITSON
}
BREAKPOINT {
UNITSOFF
syncon(v)
UNITSON
i = g * (v - erev)
}
UNITSOFF
PROCEDURE syncon(v) { LOCAL gampa, gnmda
at_time(onset)
if ( t < onset ) {
g = 0
} else {
gampa = gmaxampa * (exp(1)/tp) * (t - onset) * exp(- (t - onset) / tp)
gnmda = gmaxnmda * ( exp(- (t - onset) / tau1) - exp(- (t - onset) / tau2))
g = gampa + gnmda
}
}
UNITSON