TITLE K-A channel from Klee Ficker and Heinemann
: modified to account for Dax A Current --- M.Migliore Jun 1997
: modified to be used with cvode M.Migliore 2001
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
celsius (degC)
gkabar=.008 (mho/cm2)
vhalfn=11 (mV)
vhalfl=-56 (mV)
a0l=0.05 (/ms)
a0n=0.05 (/ms)
zetan=-1.5 (1)
zetal=3 (1)
gmn=0.55 (1)
gml=1 (1)
lmin=2 (mS)
nmin=0.1 (mS)
pw=-1 (1)
tq=-40
qq=5
q10=5
qtl=1
ek
}
NEURON {
SUFFIX kap
USEION k READ ek WRITE ik
RANGE gkabar,gka,vhalfn,vhalfl,i
GLOBAL ninf,linf,taul,taun,lmin
}
STATE {
n
l
}
ASSIGNED {
ik (mA/cm2)
i (mA/cm2)
ninf
linf
taul
taun
gka
}
INITIAL {
rates(v)
n=ninf
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gka = gkabar*n*l
i = gka*(v-ek)
ik = i
}
FUNCTION alpn(v(mV)) {
LOCAL zeta,Arg
Arg=(v-tq)/qq
if (Arg<-50) {zeta=zetan+pw}
else if (Arg>50) {zeta=zetan}
else {zeta=zetan+pw/(1+exp(Arg))}
Arg=1.e-3*zeta*(v-vhalfn)*9.648e4/(8.315*(273.16+celsius))
if (Arg<-50) {alpn=0}
else if (Arg>50) {alpn=exp(50)}
else {alpn=exp(Arg)}
}
FUNCTION betn(v(mV)) {
LOCAL zeta,Arg
Arg=(v-tq)/qq
if (Arg<-50) {zeta=zetan+pw}
else if (Arg>50) {zeta=zetan}
else {zeta=zetan+pw/(1+exp(Arg))}
Arg=1.e-3*zeta*gmn*(v-vhalfn)*9.648e4/(8.315*(273.16+celsius))
if (Arg<-50) {betn=0}
else if (Arg>50) {betn=exp(50)}
else {betn=exp(Arg)}
}
FUNCTION alpl(v (mV)) {
LOCAL Arg
Arg=1.e-3*zetal*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius))
if (Arg<-50) {alpl=0}
else if (Arg>50) {alpl=exp(50)}
else {alpl=exp(Arg)}
}
FUNCTION betl(v(mV)) {
LOCAL Arg
Arg=1.e-3*zetal*gml*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius))
if (Arg<-50) {betl=0}
else if (Arg>50) {betl=exp(50)}
else {betl=exp(Arg)}
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rates(v)
n' = (ninf - n)/taun
l' = (linf - l)/taul
}
PROCEDURE rates(v (mV)) { :callable from hoc
LOCAL a,qt
qt=q10^((celsius-24)/10)
a = alpn(v)
ninf = 1/(1 + a)
taun = betn(v)/(qt*a0n*(1+a))
if (taun<nmin) {taun=nmin}
a = alpl(v)
linf = 1/(1+ a)
taul = 0.26*(v+50)/qtl
if (taul<lmin/qtl) {taul=lmin/qtl}
}