Combe CL, Upchurch CM, Canavier CC, Gasparini S, (2022) Cholinergic Modulation Shifts the Response of CA1 Pyramidal Cells to Depolarizing Ramps via TRPM4 Channels with Implications for Place Field Firing

This model entry was contributed by C Canavier. The freely available NEURON simulation enivronment (from http://www.neuron.yale.edu) is required for this model.

To use:
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Autolaunch from modeldb if the browser is capable or compile the mod files and start with mosinit.hoc (easiest) (If you need more help to run the model, please refer to:
https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml)

On linux for example typing
nrngui init.hoc
Will generate 2 panels asking what simulation wou want to run, the first panel will produce simulations from figure 6 and figure 8 of the paper, the second panel will produce simulations from alternate morphologies:

running one of these simulations will produce a shape plot, a voltage plot, and plots of the calcium concentration in the outermost shell, nanodomain and resulting TRPM4 current

Additional running notes:
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Interspike intervals and frequencies were analyzed offline, as well as figures where variables were plotted against the injected current.