TITLE K-slow channel from Korngreen and Sakmann 2000
: M.Migliore June 2001
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
celsius (degC)
gkbar=.008 (mho/cm2)
vhalfn=-14 (mV)
vhalfl=-54 (mV)
kn=14.6 (1)
kl=-11 (1)
q10=2.3
tmp=13
ek
}
NEURON {
SUFFIX ks
USEION k READ ek WRITE ik
RANGE gkbar
GLOBAL ninf,linf,taul,taun
}
STATE {
n
l
}
ASSIGNED {
ik (mA/cm2)
ninf
linf
taul
taun
}
INITIAL {
rates(v)
n=ninf
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gkbar*n^2*l*(v-ek)
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rates(v)
n' = (ninf - n)/taun
l' = (linf - l)/taul
}
PROCEDURE rates(v (mV)) { :callable from hoc
LOCAL a,qt
qt=q10^((celsius-22)/10)
ninf = 1/(1 + exp(-(v-vhalfn)/kn))
linf = 1/(1 + exp(-(v-vhalfl)/kl))
if (v<-50) {taun = (1.25+175.03*exp(v*0.026))/qt
} else {
taun = (1.25+13*exp(-v*0.026))/qt}
taul = (360+(1010+24*(v+55))*exp(-((v+75)/48)^2))/qt
}