TITLE calcium channel (L type)
UNITS {
(molar) = (1/liter)
(S) = (siemens)
(mA) = (milliamp)
(mV) = (millivolt)
(mM) = (millimolar)
F = (faraday) (coulomb)
R = (mole k) (mV-coulomb/degC)
}
NEURON {
SUFFIX calhh
NONSPECIFIC_CURRENT incal
USEION ca READ cai WRITE ica
RANGE gcalbar,ica,ical,incal, mhalf, mslope,skcoup, pf
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
v (mV)
dt (ms)
cai (mM)
celsius = 35.0 (degC)
gcalbar = 11.196e-6 (S/cm2)
km = 0.0001 (mM)
kml = 0.00045 (mM)
eca = 120 (mV)
cao = 2.0 (mM)
skcoup = 1.0
mhalf = -30.0
mslope = 8.0
pf = 0.6
}
STATE {
dl hl
}
ASSIGNED {
ica (mA/cm2)
ical (mA/cm2)
incal (mA/cm2)
gcal (S/cm2)
dlinf
hlinf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gcal = dl*(1.0 - pf + pf*hl)
ical = gcalbar*gcal*(v-eca)
incal = (1-skcoup)*ical
ica = (skcoup)*ical
}
UNITSOFF
INITIAL {
dl = boltz(v,mhalf,5.0)
hl = boltz(v,-55,-2.0)
}
DERIVATIVE states { :Computes state variables m, h, and n
LOCAL dlinf,dhvainf,fhvainf,dltau,dhvatau,fhvatau,hltau,hlinf
:dlinf = boltz(v,-39.0,5.0) : sharper dlinf needed for SOPs
dlinf = boltz(v,mhalf,mslope)
hlinf = boltz(v,-55,-2)
dltau = gaussian(v,9.0,25.0,70.0,0.30)
hltau = 100.0 + 100.0*boltz(v,-30,-5.0)
:dltau = 5.0 + 50.0 * boltz(v,-40.0, -5.0)
:dltau = gaussian(v,25.0,10.0,50.0,5.00)
:dltau = 1.0
dl' = (dlinf-dl)/dltau
hl' = (hlinf-hl)/hltau
}
FUNCTION gaussian(v,a,b,c,d) {
LOCAL arg
arg= a*exp(-(c+v)*(v+c)/(b*b)) +d
gaussian = arg
}
FUNCTION boltz(x,y,z) {
LOCAL arg
arg= -(x-y)/z
if (arg > 50) {boltz = 0}
else {if (arg < -50) {boltz = 1}
else {boltz = 1.0/(1.0 + exp(arg))}}
}
UNITSON