/* Frankenhaeuser-Huxley action potential, Fig 1 to Fig 6 */
load_file("nrngui.hoc")
// Physical properties
create node
access node
{ nseg=1 L=2 diam=8 cm=2
insert fh
nai=13.74 nao=114.5 ki=120 ko=2.5
}
areafac = PI*L*diam/100 /* mamps/cm^2 to namps (units of 1e-6 cm^2) */
{celsius=20}
// experimental tools
objref stim
stim = new IClamp(.5)
stim.dur=.12
stim.amp = 1*areafac
// run parameters
cvode_active(1)
// graphical interface appearance
objref g
g = new Graph(0)
g.view(0, 0, 2, 100, 120, 110, 300, 200)
addplot(g,1)
// simulation control
v_init = -70
proc fig1() {
g.erase_all()
g.size(0,2.2,-5,120)
g.addexpr("v+70",2,1)
tstop = 2
run()
}
proc fig3() {
g.erase_all()
g.size(0,3,0,1)
g.addexpr("m_fh",2,1)
g.addexpr("h_fh",3,1)
g.addexpr("n_fh",4,1)
g.addexpr("p_fh",5,1)
tstop=3
run()
}
proc fig6() {
g.erase_all
g.size(0,2,-10,5)
g.addexpr("ina",2,1)
g.addexpr("ik",3,1)
g.addexpr("ip_fh",4,1)
g.addexpr("il_fh",5,1)
tstop = 2
run()
}
proc menu() {
xpanel("Frankenhaeuser-Huxley action potential")
xbutton("fig 1", "fig1()")
xbutton("fig 3", "fig3()")
xbutton("fig 6", "fig6()")
xpanel(0,100)
}
// run simulation
menu()