COMMENT
Slavish transliteration of equation from Purvis & Butera 2005.
Not a remapping of their Ca accum mechanism in a form that would use density parameters.
Cannot be used outside of the context of their model
(K1 implicitly assumes a particular volume and surface/volume ratio, which
depend on cell geometry).
In the absence of calcium currents, cai will monoexponentially decay toward 0.
ENDCOMMENT
NEURON {
SUFFIX cax
USEION ca READ ica WRITE cai
RANGE K1, K2
}
UNITS {
(mM) = (milli/liter)
(mA) = (milliamp)
F = (faraday) (coulombs)
}
PARAMETER {
K1 = 0.02 (mM-cm2/ms-mA)
K2 = 0.04 (/ms)
cai0 = 0.0000604 (mM)
}
ASSIGNED {
ica (mA/cm2)
}
STATE {
cai (mM)
}
INITIAL {
cai = cai0
}
BREAKPOINT {
SOLVE integrate METHOD derivimplicit
}
DERIVATIVE integrate {
cai' = -(K1*ica + K2*cai)
}