TITLE I-h channel from Magee 1998 for distal dendrites
: default values are for dendrites and low Na
: plus leakage, M.Migliore Mar 2010
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
ehd (mV)
celsius (degC)
ghdbar=.0001 (mho/cm2)
vhalfl=-77.457 (mV)
vhalft=-70.242 (mV)
a0t=0.0046744 (/ms)
zetal=3.4798 (1)
zetat=7.3336 (1)
gmt=0.14472 (1)
q10=4.5
qtl=1
clk=0.24064
elk = -70 (mV)
sh=0
}
NEURON {
THREADSAFE SUFFIX hdpas
NONSPECIFIC_CURRENT i
NONSPECIFIC_CURRENT lk
RANGE ghdbar, elk, glk, sh
GLOBAL linf, taul, clk, vhalfl
}
STATE {
l
}
ASSIGNED {
i (mA/cm2)
lk (mA/cm2)
linf
taul
ghd
glk
}
INITIAL {
rate(v)
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ghd = ghdbar*l
i = ghd*(v-ehd)
lk = clk*ghdbar*(v-elk)
}
FUNCTION alpl(v(mV)) {
alpl = exp(0.0378*zetal*(v-vhalfl-sh))
}
FUNCTION alpt(v(mV)) {
alpt = exp(0.0378*zetat*(v-vhalft-sh))
}
FUNCTION bett(v(mV)) {
bett = exp(0.0378*zetat*gmt*(v-vhalft-sh))
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rate(v)
l' = (linf - l)/taul
}
PROCEDURE rate(v (mV)) { :callable from hoc
LOCAL a,qt
qt=q10^((celsius-33)/10)
a = alpt(v)
linf = 1/(1+ alpl(v))
taul = bett(v)/(qtl*qt*a0t*(1+a))
}