<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
  <model>
    <listOfUnitDefinitions>
      <unitDefinition id="substance">
        <listOfUnits>
          <unit kind="mole" exponent="1" scale="-9" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="time">
        <listOfUnits>
          <unit kind="second" exponent="1" scale="-3" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="volume">
        <listOfUnits>
          <unit kind="litre" exponent="1" scale="0" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="area">
        <listOfUnits>
          <unit kind="metre" exponent="2" scale="-6" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="length">
        <listOfUnits>
          <unit kind="metre" exponent="1" scale="-6" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="nM">
        <listOfUnits>
          <unit kind="mole" exponent="1" scale="-9" multiplier="1"/>
          <unit kind="litre" exponent="-1" scale="0" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="one_over_ms">
        <listOfUnits>
          <unit kind="dimensionless" exponent="1" scale="0" multiplier="1"/>
          <unit kind="second" exponent="-1" scale="-3" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="one_over_nM_ms">
        <listOfUnits>
          <unit kind="dimensionless" exponent="1" scale="0" multiplier="1"/>
          <unit kind="mole" exponent="-1" scale="-9" multiplier="1"/>
          <unit kind="litre" exponent="1" scale="0" multiplier="1"/>
          <unit kind="second" exponent="-1" scale="-3" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="nM_per_ms">
        <listOfUnits>
          <unit kind="mole" exponent="1" scale="-9" multiplier="1"/>
          <unit kind="litre" exponent="-1" scale="0" multiplier="1"/>
          <unit kind="second" exponent="-1" scale="-3" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="liter">
        <listOfUnits>
          <unit kind="litre" exponent="1" scale="0" multiplier="1"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <listOfCompartments>
      <compartment id="Compartment" name="Compartment" size="1" units="liter"/>
    </listOfCompartments>
    <listOfSpecies>
      <species id="gaba" name="gaba" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="gabaGABABR" name="gabaGABABR" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="gabaGABABRGi" name="gabaGABABRGi" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="gabaGABABRGibg" name="gabaGABABRGibg" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GABABR" name="GABABR" compartment="Compartment" initialConcentration="400" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GABABRGi" name="GABABRGi" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="Gi" name="Gi" compartment="Compartment" initialConcentration="2600" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GiaGDP" name="GiaGDP" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GiaGTP" name="GiaGTP" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GiaGTPRGS" name="GiaGTPRGS" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="Gibg" name="Gibg" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GIRK" name="GIRK" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GIRKGibg" name="GIRKGibg" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GIRKGibg2" name="GIRKGibg2" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GIRKGibg3" name="GIRKGibg3" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="GIRKGibg4" name="GIRKGibg4" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="RGS" name="RGS" compartment="Compartment" initialConcentration="1000" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="VGCC" name="VGCC" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="VGCCGibg" name="VGCCGibg" compartment="Compartment" initialConcentration="0" substanceUnits="substance" hasOnlySubstanceUnits="false"/>
      <species id="oGIRKGibg4" name="oGIRKGibg4" compartment="Compartment" initialConcentration="0" substanceUnits="substance" boundaryCondition="true"/>
      <species id="oVGCCGibg" name="oVGCCGibg" compartment="Compartment" initialConcentration="0" substanceUnits="substance" boundaryCondition="true"/>
      <species id="ogaba" name="ogaba" compartment="Compartment" initialConcentration="0" substanceUnits="substance" boundaryCondition="true"/>
    </listOfSpecies>
    <listOfParameters>
      <parameter id="kf_R0" name="kf_R0" value="0.0535168989262411" units="one_over_ms"/>
      <parameter id="kf_R1" name="kf_R1" value="0.00285888595867763" units="one_over_nM_ms"/>
      <parameter id="kr_R1" name="kr_R1" value="0.314477455454539" units="one_over_ms"/>
      <parameter id="kf_R2" name="kf_R2" value="0.0251449235770638" units="one_over_nM_ms"/>
      <parameter id="kr_R2" name="kr_R2" value="0.0419082059617731" units="one_over_ms"/>
      <parameter id="kf_R3" name="kf_R3" value="0.0209541029808865" units="one_over_ms"/>
      <parameter id="kf_R4" name="kf_R4" value="0.167632823847092" units="one_over_ms"/>
      <parameter id="kf_R5" name="kf_R5" value="0.0125724617885319" units="one_over_nM_ms"/>
      <parameter id="kr_R5" name="kr_R5" value="0.0209541029808865" units="one_over_ms"/>
      <parameter id="kf_R6" name="kf_R6" value="0.00285888595867763" units="one_over_nM_ms"/>
      <parameter id="kr_R6" name="kr_R6" value="0.314477455454539" units="one_over_ms"/>
      <parameter id="kf_R7" name="kf_R7" value="2e-06" units="one_over_nM_ms"/>
      <parameter id="kr_R7" name="kr_R7" value="0.002" units="one_over_ms"/>
      <parameter id="kf_R8" name="kf_R8" value="0.03" units="one_over_ms"/>
      <parameter id="kf_R9" name="kf_R9" value="0.00125" units="one_over_nM_ms"/>
      <parameter id="kf_R10" name="kf_R10" value="0.000154358980053402" units="one_over_nM_ms"/>
      <parameter id="kr_R10" name="kr_R10" value="0.0669308830676273" units="one_over_ms"/>
      <parameter id="kf_R11" name="kf_R11" value="0.000154358980053402" units="one_over_nM_ms"/>
      <parameter id="kr_R11" name="kr_R11" value="0.0669308830676273" units="one_over_ms"/>
      <parameter id="kf_R12" name="kf_R12" value="0.000154358980053402" units="one_over_nM_ms"/>
      <parameter id="kr_R12" name="kr_R12" value="0.0669308830676273" units="one_over_ms"/>
      <parameter id="kf_R13" name="kf_R13" value="0.000154358980053402" units="one_over_nM_ms"/>
      <parameter id="kr_R13" name="kr_R13" value="0.0669308830676273" units="one_over_ms"/>
      <parameter id="kf_R14" name="kf_R14" value="0.000154358980053402" units="one_over_nM_ms"/>
      <parameter id="kr_R14" name="kr_R14" value="0.0669308830676273" units="one_over_ms"/>
      <parameter id="k_gaba" name="k_gaba" value="0" units="nM_per_ms"/>
    </listOfParameters>
    <listOfRules>
      <assignmentRule variable="oGIRKGibg4">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <ci> GIRKGibg4 </ci>
        </math>
      </assignmentRule>
      <assignmentRule variable="oVGCCGibg">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <ci> VGCCGibg </ci>
        </math>
      </assignmentRule>
      <assignmentRule variable="ogaba">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <ci> gaba </ci>
        </math>
      </assignmentRule>
    </listOfRules>
    <listOfReactions>
      <reaction id="R0" name="R0" reversible="true">
        <listOfProducts>
          <speciesReference species="gaba"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <ci> k_gaba </ci>
                <apply>
                  <times/>
                  <ci> kf_R0 </ci>
                  <ci> gaba </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R1" name="R1" reversible="true">
        <listOfReactants>
          <speciesReference species="gaba"/>
          <speciesReference species="GABABR"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="gabaGABABR"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R1 </ci>
                  <ci> gaba </ci>
                  <ci> GABABR </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R1 </ci>
                  <ci> gabaGABABR </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R2" name="R2" reversible="true">
        <listOfReactants>
          <speciesReference species="gabaGABABR"/>
          <speciesReference species="Gi"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="gabaGABABRGi"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R2 </ci>
                  <ci> gabaGABABR </ci>
                  <ci> Gi </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R2 </ci>
                  <ci> gabaGABABRGi </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R3" name="R3" reversible="false">
        <listOfReactants>
          <speciesReference species="gabaGABABRGi"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="gabaGABABRGibg"/>
          <speciesReference species="GiaGTP"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kf_R3 </ci>
              <ci> gabaGABABRGi </ci>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R4" name="R4" reversible="false">
        <listOfReactants>
          <speciesReference species="gabaGABABRGibg"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="gabaGABABR"/>
          <speciesReference species="Gibg"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kf_R4 </ci>
              <ci> gabaGABABRGibg </ci>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R5" name="R5" reversible="true">
        <listOfReactants>
          <speciesReference species="GABABR"/>
          <speciesReference species="Gi"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GABABRGi"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R5 </ci>
                  <ci> GABABR </ci>
                  <ci> Gi </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R5 </ci>
                  <ci> GABABRGi </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R6" name="R6" reversible="true">
        <listOfReactants>
          <speciesReference species="gaba"/>
          <speciesReference species="GABABRGi"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="gabaGABABRGi"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R6 </ci>
                  <ci> gaba </ci>
                  <ci> GABABRGi </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R6 </ci>
                  <ci> gabaGABABRGi </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R7" name="R7" reversible="true">
        <listOfReactants>
          <speciesReference species="GiaGTP"/>
          <speciesReference species="RGS"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GiaGTPRGS"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R7 </ci>
                  <ci> GiaGTP </ci>
                  <ci> RGS </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R7 </ci>
                  <ci> GiaGTPRGS </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R8" name="R8" reversible="false">
        <listOfReactants>
          <speciesReference species="GiaGTPRGS"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GiaGDP"/>
          <speciesReference species="RGS"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kf_R8 </ci>
              <ci> GiaGTPRGS </ci>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R9" name="R9" reversible="false">
        <listOfReactants>
          <speciesReference species="GiaGDP"/>
          <speciesReference species="Gibg"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Gi"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kf_R9 </ci>
              <ci> GiaGDP </ci>
              <ci> Gibg </ci>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R10" name="R10" reversible="true">
        <listOfReactants>
          <speciesReference species="GIRK"/>
          <speciesReference species="Gibg"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GIRKGibg"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R10 </ci>
                  <ci> GIRK </ci>
                  <ci> Gibg </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R10 </ci>
                  <ci> GIRKGibg </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R11" name="R11" reversible="true">
        <listOfReactants>
          <speciesReference species="GIRKGibg"/>
          <speciesReference species="Gibg"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GIRKGibg2"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R11 </ci>
                  <ci> GIRKGibg </ci>
                  <ci> Gibg </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R11 </ci>
                  <ci> GIRKGibg2 </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R12" name="R12" reversible="true">
        <listOfReactants>
          <speciesReference species="GIRKGibg2"/>
          <speciesReference species="Gibg"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GIRKGibg3"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R12 </ci>
                  <ci> GIRKGibg2 </ci>
                  <ci> Gibg </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R12 </ci>
                  <ci> GIRKGibg3 </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R13" name="R13" reversible="true">
        <listOfReactants>
          <speciesReference species="GIRKGibg3"/>
          <speciesReference species="Gibg"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="GIRKGibg4"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R13 </ci>
                  <ci> GIRKGibg3 </ci>
                  <ci> Gibg </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R13 </ci>
                  <ci> GIRKGibg4 </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="R14" name="R14" reversible="true">
        <listOfReactants>
          <speciesReference species="VGCC"/>
          <speciesReference species="Gibg"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="VGCCGibg"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci> kf_R14 </ci>
                  <ci> VGCC </ci>
                  <ci> Gibg </ci>
                </apply>
                <apply>
                  <times/>
                  <ci> kr_R14 </ci>
                  <ci> VGCCGibg </ci>
                </apply>
              </apply>
              <ci> Compartment </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>