<?xml version="1.0" ?> <VectorField Name="GABAB_signaling" Description="model created by an R script «sbtab_to_vfgen.R» (https://github.com/a-kramer/SBtabVFGEN)"> <Parameter Name="kf_R0" Description="independent parameter" DefaultValue="0.0535169"/> <Parameter Name="kf_R1" Description="independent parameter" DefaultValue="0.00285889"/> <Parameter Name="kr_R1" Description="independent parameter" DefaultValue="0.314477"/> <Parameter Name="kf_R2" Description="independent parameter" DefaultValue="0.0251449"/> <Parameter Name="kr_R2" Description="independent parameter" DefaultValue="0.0419082"/> <Parameter Name="kf_R3" Description="independent parameter" DefaultValue="0.0209541"/> <Parameter Name="kf_R4" Description="independent parameter" DefaultValue="0.167633"/> <Parameter Name="kf_R5" Description="independent parameter" DefaultValue="0.0125725"/> <Parameter Name="kr_R5" Description="independent parameter" DefaultValue="0.0209541"/> <Parameter Name="kf_R6" Description="independent parameter" DefaultValue="0.00285889"/> <Parameter Name="kr_R6" Description="independent parameter" DefaultValue="0.314477"/> <Parameter Name="kf_R7" Description="independent parameter" DefaultValue="2e-06"/> <Parameter Name="kr_R7" Description="independent parameter" DefaultValue="0.002"/> <Parameter Name="kf_R8" Description="independent parameter" DefaultValue="0.03"/> <Parameter Name="kf_R9" Description="independent parameter" DefaultValue="0.00125"/> <Parameter Name="kf_R10" Description="independent parameter" DefaultValue="0.000154359"/> <Parameter Name="kr_R10" Description="independent parameter" DefaultValue="0.0669309"/> <Parameter Name="kf_R11" Description="independent parameter" DefaultValue="0.000154359"/> <Parameter Name="kr_R11" Description="independent parameter" DefaultValue="0.0669309"/> <Parameter Name="kf_R12" Description="independent parameter" DefaultValue="0.000154359"/> <Parameter Name="kr_R12" Description="independent parameter" DefaultValue="0.0669309"/> <Parameter Name="kf_R13" Description="independent parameter" DefaultValue="0.000154359"/> <Parameter Name="kr_R13" Description="independent parameter" DefaultValue="0.0669309"/> <Parameter Name="kf_R14" Description="independent parameter" DefaultValue="0.000154359"/> <Parameter Name="kr_R14" Description="independent parameter" DefaultValue="0.0669309"/> <Parameter Name="k_gaba" Description="input parameter" DefaultValue="0"/> <Expression Name="R0" Description="flux" Formula="k_gaba - kf_R0*gaba"/> <Expression Name="R1" Description="flux" Formula="kf_R1*gaba*GABABR-kr_R1*gabaGABABR"/> <Expression Name="R2" Description="flux" Formula="kf_R2*gabaGABABR*Gi-kr_R2*gabaGABABRGi"/> <Expression Name="R3" Description="flux" Formula="kf_R3*gabaGABABRGi"/> <Expression Name="R4" Description="flux" Formula="kf_R4*gabaGABABRGibg"/> <Expression Name="R5" Description="flux" Formula="kf_R5*GABABR*Gi-kr_R5*GABABRGi"/> <Expression Name="R6" Description="flux" Formula="kf_R6*gaba*GABABRGi-kr_R6*gabaGABABRGi"/> <Expression Name="R7" Description="flux" Formula="kf_R7*GiaGTP*RGS-kr_R7*GiaGTPRGS"/> <Expression Name="R8" Description="flux" Formula="kf_R8*GiaGTPRGS"/> <Expression Name="R9" Description="flux" Formula="kf_R9*GiaGDP*Gibg"/> <Expression Name="R10" Description="flux" Formula="kf_R10*GIRK*Gibg-kr_R10*GIRKGibg"/> <Expression Name="R11" Description="flux" Formula="kf_R11*GIRKGibg*Gibg-kr_R11*GIRKGibg2"/> <Expression Name="R12" Description="flux" Formula="kf_R12*GIRKGibg2*Gibg-kr_R12*GIRKGibg3"/> <Expression Name="R13" Description="flux" Formula="kf_R13*GIRKGibg3*Gibg-kr_R13*GIRKGibg4"/> <Expression Name="R14" Description="flux" Formula="kf_R14*VGCC*Gibg-kr_R14*VGCCGibg"/> <StateVariable Name="gaba" Description="compound" DefaultInitialCondition="0" Formula="+R0-R1-R6"/> <StateVariable Name="gabaGABABR" Description="compound" DefaultInitialCondition="0" Formula="+R1-R2+R4"/> <StateVariable Name="gabaGABABRGi" Description="compound" DefaultInitialCondition="0" Formula="+R2-R3+R6"/> <StateVariable Name="gabaGABABRGibg" Description="compound" DefaultInitialCondition="0" Formula="+R3-R4"/> <StateVariable Name="GABABR" Description="compound" DefaultInitialCondition="400" Formula="-R1-R5"/> <StateVariable Name="GABABRGi" Description="compound" DefaultInitialCondition="0" Formula="+R5-R6"/> <StateVariable Name="Gi" Description="compound" DefaultInitialCondition="2600" Formula="-R2-R5+R9"/> <StateVariable Name="GiaGDP" Description="compound" DefaultInitialCondition="0" Formula="+R8-R9"/> <StateVariable Name="GiaGTP" Description="compound" DefaultInitialCondition="0" Formula="+R3-R7"/> <StateVariable Name="GiaGTPRGS" Description="compound" DefaultInitialCondition="0" Formula="+R7-R8"/> <StateVariable Name="Gibg" Description="compound" DefaultInitialCondition="0" Formula="+R4-R9-R10-R11-R12-R13-R14"/> <StateVariable Name="GIRK" Description="compound" DefaultInitialCondition="0" Formula="-R10"/> <StateVariable Name="GIRKGibg" Description="compound" DefaultInitialCondition="0" Formula="+R10-R11"/> <StateVariable Name="GIRKGibg2" Description="compound" DefaultInitialCondition="0" Formula="+R11-R12"/> <StateVariable Name="GIRKGibg3" Description="compound" DefaultInitialCondition="0" Formula="+R12-R13"/> <StateVariable Name="GIRKGibg4" Description="compound" DefaultInitialCondition="0" Formula="+R13"/> <StateVariable Name="RGS" Description="compound" DefaultInitialCondition="1000" Formula="-R7+R8"/> <StateVariable Name="VGCC" Description="compound" DefaultInitialCondition="0" Formula="-R14"/> <StateVariable Name="VGCCGibg" Description="compound" DefaultInitialCondition="0" Formula="+R14"/> <Function Name="oGIRKGibg4" Description="output" Formula="GIRKGibg4"/> <Function Name="oVGCCGibg" Description="output" Formula="VGCCGibg"/> <Function Name="ogaba" Description="output" Formula="gaba"/> </VectorField> <!-- VFGEN doesn't have a Transformation mechanism, the following matter will not be parsed by the vfgen tool --> <Appendix> <Transformation Name="on"> <Assign Name="kf_R1" Type="par" Formula="kf_R1"/> <Assign Name="kr_R1" Type="par" Formula="kr_R1"/> <Assign Name="kf_R2" Type="par" Formula="kf_R2"/> <Assign Name="kr_R2" Type="par" Formula="kr_R2"/> <Assign Name="kf_R3" Type="par" Formula="kf_R3"/> <Assign Name="kf_R4" Type="par" Formula="kf_R4"/> <Assign Name="kf_R5" Type="par" Formula="kf_R5"/> <Assign Name="kr_R5" Type="par" Formula="kr_R5"/> <Assign Name="kf_R6" Type="par" Formula="kf_R6"/> <Assign Name="kr_R6" Type="par" Formula="kr_R6"/> <Assign Name="kf_R7" Type="par" Formula="kf_R7"/> <Assign Name="kr_R7" Type="par" Formula="kr_R7"/> <Assign Name="kf_R8" Type="par" Formula="kf_R8"/> <Assign Name="kf_R9" Type="par" Formula="kf_R9"/> <Assign Name="kf_R10" Type="par" Formula="kf_R10"/> <Assign Name="kr_R10" Type="par" Formula="kr_R10"/> <Assign Name="kf_R11" Type="par" Formula="kf_R11"/> <Assign Name="kr_R11" Type="par" Formula="kr_R11"/> <Assign Name="kf_R12" Type="par" Formula="kf_R12"/> <Assign Name="kr_R12" Type="par" Formula="kr_R12"/> <Assign Name="kf_R13" Type="par" Formula="kf_R13"/> <Assign Name="kr_R13" Type="par" Formula="kr_R13"/> <Assign Name="kf_R14" Type="par" Formula="kf_R14"/> <Assign Name="kr_R14" Type="par" Formula="kr_R14"/> <Assign Name="k_gaba" Type="par" Formula="100"/> <Assign Name="gaba" Type="var" Formula="gaba"/> <Assign Name="gabaGABABR" Type="var" Formula="gabaGABABR"/> <Assign Name="gabaGABABRGi" Type="var" Formula="gabaGABABRGi"/> <Assign Name="gabaGABABRGibg" Type="var" Formula="gabaGABABRGibg"/> <Assign Name="GABABR" Type="var" Formula="GABABR"/> <Assign Name="GABABRGi" Type="var" Formula="GABABRGi"/> <Assign Name="Gi" Type="var" Formula="Gi"/> <Assign Name="GiaGDP" Type="var" Formula="GiaGDP"/> <Assign Name="GiaGTP" Type="var" Formula="GiaGTP"/> <Assign Name="GiaGTPRGS" Type="var" Formula="GiaGTPRGS"/> <Assign Name="Gibg" Type="var" Formula="Gibg"/> <Assign Name="GIRK" Type="var" Formula="GIRK"/> <Assign Name="GIRKGibg" Type="var" Formula="GIRKGibg"/> <Assign Name="GIRKGibg2" Type="var" Formula="GIRKGibg2"/> <Assign Name="GIRKGibg3" Type="var" Formula="GIRKGibg3"/> <Assign Name="GIRKGibg4" Type="var" Formula="GIRKGibg4"/> <Assign Name="RGS" Type="var" Formula="RGS"/> <Assign Name="VGCC" Type="var" Formula="VGCC"/> <Assign Name="VGCCGibg" Type="var" Formula="VGCCGibg"/> </Transformation> <Transformation Name="off"> <Assign Name="kf_R0" Type="par" Formula="kf_R0"/> <Assign Name="kr_R1" Type="par" Formula="kr_R1"/> <Assign Name="kf_R2" Type="par" Formula="kf_R2"/> <Assign Name="kr_R2" Type="par" Formula="kr_R2"/> <Assign Name="kf_R3" Type="par" Formula="kf_R3"/> <Assign Name="kf_R4" Type="par" Formula="kf_R4"/> <Assign Name="kf_R5" Type="par" Formula="kf_R5"/> <Assign Name="kr_R5" Type="par" Formula="kr_R5"/> <Assign Name="kf_R6" Type="par" Formula="kf_R6"/> <Assign Name="kr_R6" Type="par" Formula="kr_R6"/> <Assign Name="kf_R7" Type="par" Formula="kf_R7"/> <Assign Name="kr_R7" Type="par" Formula="kr_R7"/> <Assign Name="kf_R8" Type="par" Formula="kf_R8"/> <Assign Name="kf_R9" Type="par" Formula="kf_R9"/> <Assign Name="kf_R10" Type="par" Formula="kf_R10"/> <Assign Name="kr_R10" Type="par" Formula="kr_R10"/> <Assign Name="kf_R11" Type="par" Formula="kf_R11"/> <Assign Name="kr_R11" Type="par" Formula="kr_R11"/> <Assign Name="kf_R12" Type="par" Formula="kf_R12"/> <Assign Name="kr_R12" Type="par" Formula="kr_R12"/> <Assign Name="kf_R13" Type="par" Formula="kf_R13"/> <Assign Name="kr_R13" Type="par" Formula="kr_R13"/> <Assign Name="kf_R14" Type="par" Formula="kf_R14"/> <Assign Name="kr_R14" Type="par" Formula="kr_R14"/> <Assign Name="k_gaba" Type="par" Formula="0"/> <Assign Name="gaba" Type="var" Formula="gaba"/> <Assign Name="gabaGABABR" Type="var" Formula="gabaGABABR"/> <Assign Name="gabaGABABRGi" Type="var" Formula="gabaGABABRGi"/> <Assign Name="gabaGABABRGibg" Type="var" Formula="gabaGABABRGibg"/> <Assign Name="GABABR" Type="var" Formula="GABABR"/> <Assign Name="GABABRGi" Type="var" Formula="GABABRGi"/> <Assign Name="Gi" Type="var" Formula="Gi"/> <Assign Name="GiaGDP" Type="var" Formula="GiaGDP"/> <Assign Name="GiaGTP" Type="var" Formula="GiaGTP"/> <Assign Name="GiaGTPRGS" Type="var" Formula="GiaGTPRGS"/> <Assign Name="Gibg" Type="var" Formula="Gibg"/> <Assign Name="GIRK" Type="var" Formula="GIRK"/> <Assign Name="GIRKGibg" Type="var" Formula="GIRKGibg"/> <Assign Name="GIRKGibg2" Type="var" Formula="GIRKGibg2"/> <Assign Name="GIRKGibg3" Type="var" Formula="GIRKGibg3"/> <Assign Name="GIRKGibg4" Type="var" Formula="GIRKGibg4"/> <Assign Name="RGS" Type="var" Formula="RGS"/> <Assign Name="VGCC" Type="var" Formula="VGCC"/> <Assign Name="VGCCGibg" Type="var" Formula="VGCCGibg"/> </Transformation> </Appendix>