These files are for the modeling associated with the paper: Geiger JR, Lubke J, Roth A, Frotscher M, Jonas P. Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron 1997 Jun;18(6):1009-23 Abstract: Glutamatergic transmission at a principal neuron-interneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis. Evoked EPSPs with rapid time course (half duration = 4 ms; 34 degrees C) were generated at multiple synaptic contacts established on the interneuron dendrites close to the soma. The underlying postsynaptic conductance change showed a submillisecond rise and decay, due to the precise timing of glutamate release and the rapid deactivation of the postsynaptic AMPA receptors. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity. For Auto-launch... One can create figures similar to fig8b and fig 8c from the paper by hand once the program has started. Pressing the "Estimate of fig 8d" button leads to the generation of a figure similar to the one in the paper. See the fig8d.hoc file for modifications for higher resolution. ------- for manual running... After the mod file is compiled to make the syn2 mechanism available currentclamp.hoc can be run with the procedure suitable for your platform.