// Geometry-induced features of current transfer in neuronal dendrites with tonically activated conductances
// Sergey M. Korogod, Irina B. Kulagina
// Biol. Cybern. 79, 231-240 (1998)

objectvar JRGraph, IRGraph

// define membrane mechanisms
proc SetMembrane() {
  strdef OutLine
  OutLine = "Soma {insert PasSA}"
  execute1(OutLine)
  OutLine = "Axon {insert PasSA}"
  execute1(OutLine)
  OutLine = "Dendrite {insert PasD}"
  execute1(OutLine)
} // SetMembrane()

func CalcJm() { local Gm, Eq, Jm // uA/cm2
  if (issection("Dendrite")) {
    Gm = gs_PasD($1) + g_PasD($1)
    Eq = ((gs_PasD($1) / Gm) * es_PasD($1)) + ((g_PasD($1) / Gm) * erev_PasD($1))
    Jm = (Gm * (v($1) - Eq)) * 1000
  } else {
    Jm = (g_PasSA($1) * (v($1) - erev_PasSA($1))) * 1000
  }
  return Jm
} // CalcJm()

// make graphics for Fig.2. A
proc MakeJRGraph() {
  strdef OutLine
  JRGraph = new Graph(0)
  JRGraph.xaxis()
  JRGraph.yaxis()
  RRGraph = new RangeVarPlot("CalcJm($1)")
  OutLine = "Axon RRGraph.begin(0) Dendrite RRGraph.end(1)"
  execute1(OutLine)
  JRGraph.addobject(RRGraph, 1, 1, 1, 1)
  JRGraph.size(-200, 800, -4, 6)
  JRGraph.view(-200, -4.2, 1000, 10.2, 268, 200, 300.0, 215.0)
  JRGraph.label(0.5, 1, "A", 2, 1, 0, 1, 1)
  JRGraph.label(0.05, 1, "uA/cm2", 2, 1, 0, 1, 1)
  JRGraph.label(0.9, 0.2, "um", 2, 1, 0, 1, 1)
  JRGraph.yaxis(3)
  JRGraph.xaxis(-200, 800, -4, 10, 0, 0, 1)
  JRGraph.xaxis(-200, 800, 0, 0, 0, 0, 0)
  JRGraph.yaxis(-4, 6, -200, 10, 0, 0, 1)
  flush_list.append(JRGraph)
  JRGraph.save_name("flush_list.")
  objectvar RRGraph
} // MakeJRGraph()

func CalcI() { local Gm, Eq, Jm, Im // 0.01*pA/um
  if (issection("Dendrite")) {
    Gm = gs_PasD($1) + g_PasD($1)
    Eq = ((gs_PasD($1) / Gm) * es_PasD($1)) + ((g_PasD($1) / Gm) * erev_PasD($1))
    Jm = (Gm * (v($1) - Eq)) * 1000
  } else {
    Jm = (g_PasSA($1) * (v($1) - erev_PasSA($1))) * 1000
  }
  Im = -(PI * diam($1) * Jm)
  return Im
} // CalcI()

// make graphics for Fig.2. C
proc MakeIRGraph() {
  strdef OutLine
  max_distance = 0
  route_distance = 0
  IRGraph = new Graph(0)
  IRGraph.xaxis()
  IRGraph.yaxis()
  RRGraph = new RangeVarPlot("CalcI($1)")
  OutLine = "Axon RRGraph.begin(0) Dendrite RRGraph.end(1)"
  execute1(OutLine)
  IRGraph.addobject(RRGraph, 1, 1, 1, 1)
  IRGraph.size(-200, 800, -500, 100)
  IRGraph.view(-220, -510, 1020, 610, 683, 200, 300.0, 215.0)
  IRGraph.label(0.5, 1, "C", 2, 1, 0, 1, 1)
  IRGraph.label(0.05, 1, "0.01 pA/um", 2, 1, 0, 1, 1)
  IRGraph.label(0.9, 0.18, "um", 2, 1, 0, 1, 1)
  IRGraph.yaxis(3)
  IRGraph.xaxis(-200, 800, -500, 10, 0, 0, 1)
  IRGraph.xaxis(-200, 800, 0, 0, 0, 0, 0)
  IRGraph.yaxis(-500, 100, -200, 6, 0, 0, 1)
  flush_list.append(IRGraph)
  IRGraph.save_name("flush_list.")
  objectvar RRGraph
} // MakeIRGraph()

proc Destroy() {
  JRGraph.unmap()
  IRGraph.unmap()
} // Destroy()

proc MainExec() {
  GetModelTopology(1)
  SetMembrane()
  OutLine = "access Soma"
  execute1(OutLine)
  tstop = 100
  MakeJRGraph()
  MakeIRGraph()
} // MainExec()

MainExec()