// genesis - gnrh compartment definitions // Steve Van Hooser 9/98 (modified from Dieter Jaeger's gpkit) // A. Tobin 2/01 (modified from D. Jaeger's gpkit) // C. B. Roberts 8/04 (modified from above for gnrh neurons) /************************************************************* * Sets up passive membrane gnrh cell compartment prototypes * Compartment types: * soma dendrite synaptic contacts neurite neurax1,2,3 axon * ***************************************************************/ function make_gnrh_comps /* separate function so we can have local variables */ float len, dia, surf int i echo Making gnrh active compartment library... /******************************SOMA*****************************/ len = 0.00e-6 dia = 20.0e-6 surf = dia*dia*{PI} if (!({exists gnrh_soma})) create compartment gnrh_soma end setfield gnrh_soma Cm {{CM}*surf} Ra {8.0*{RA}/(dia*{PI})} \ Em {ELEAK} initVm {EREST_ACT} Rm {{RMs}/surf} \ inject 0.0 dia {dia} len {len} copy NaF_gnrh gnrh_soma/NaF addmsg gnrh_soma gnrh_soma/NaF VOLTAGE Vm addmsg gnrh_soma/NaF gnrh_soma CHANNEL Gk Ek setfield gnrh_soma/NaF Gbar {{GNaFs}*surf} copy Kdr_gnrh gnrh_soma/Kdr addmsg gnrh_soma gnrh_soma/Kdr VOLTAGE Vm addmsg gnrh_soma/Kdr gnrh_soma CHANNEL Gk Ek setfield gnrh_soma/Kdr Gbar {{GKdrs}*surf} copy CaL_gnrh gnrh_soma/CaL addmsg gnrh_soma gnrh_soma/CaL VOLTAGE Vm addmsg gnrh_soma/CaL gnrh_soma CHANNEL Gk Ek setfield gnrh_soma/CaL Gbar {{GCaLs}*surf} /***************************DENDRITE***************************/ len = 200.00e-6 dia = 2.00e-6 surf = len*dia*{PI} if (!({exists gnrh_dendrite})) create compartment gnrh_dendrite end setfield gnrh_dendrite Cm {{CM}*surf} Ra {4.0*{RA}*len/(dia*dia*{PI})} \ Em {ELEAK} initVm {EREST_ACT} Rm {{RMs}/surf} inject 0.0 \ dia {dia} len {len} /* copy NaF_gnrh gnrh_dendrite/NaF addmsg gnrh_dendrite gnrh_dendrite/NaF VOLTAGE Vm addmsg gnrh_dendrite/NaF gnrh_dendrite CHANNEL Gk Ek setfield gnrh_dendrite/NaF Gbar {{GNaFd}*surf} copy Kdr_gnrh gnrh_dendrite/Kdr addmsg gnrh_dendrite gnrh_dendrite/Kdr VOLTAGE Vm addmsg gnrh_dendrite/Kdr gnrh_dendrite CHANNEL Gk Ek setfield gnrh_dendrite/Kdr Gbar {{GKdrd}*surf} */ /****************************AXON *****************************/ len = 200.00e-6 dia = 2.00e-6 surf = len*dia*{PI} if (!({exists gnrh_axon})) create compartment gnrh_axon end setfield gnrh_axon Cm {{CM}*surf} Ra {4.0*{RA}*len/(dia*dia*{PI})} \ Em {ELEAK} initVm {EREST_ACT} Rm {{RMs}/surf} inject 0.0 \ dia {dia} len {len} copy NaF_gnrh gnrh_axon/NaF addmsg gnrh_axon gnrh_axon/NaF VOLTAGE Vm addmsg gnrh_axon/NaF gnrh_axon CHANNEL Gk Ek setfield gnrh_axon/NaF Gbar {{GNaFa}*surf} copy Kdr_gnrh gnrh_axon/Kdr addmsg gnrh_axon gnrh_axon/Kdr VOLTAGE Vm addmsg gnrh_axon/Kdr gnrh_axon CHANNEL Gk Ek setfield gnrh_axon/Kdr Gbar {{GKdra}*surf} copy CaL_gnrh gnrh_axon/CaL addmsg gnrh_axon gnrh_axon/CaL VOLTAGE Vm addmsg gnrh_axon/CaL gnrh_axon CHANNEL Gk Ek setfield gnrh_axon/CaL Gbar {{GCaLa}*surf} end // actual code pushe library //make_gnrh_comps pope