########################################################################### # This model has a delayed rectifier, a leak and # a sodium current based on the famous Traub and Miles model but with changes put in # by Bard Ermerntrout in linearization of F-I curves by adaptation, Neural computation, # 10:1721-9, 1998 # # Input Currents are in nA, maximal conductances in mS/cm2, membrane potential # in mV time in ms,and capacitance in uF/cm2 ############################################################################ #adjust defaults for xpp internal variables @ MAXSTOR=40000 @ YP=v @ TOTAL=1000 @ DT=0.05 @ BOUND=100000 @ XHI=1000 @ YLO=-100 @ YHI=50 #@ METH=gear @ BACKGROUND=white # parameters par gbarNa=80 par gbarK=80 par gleak=0.2 par C=1., i=0.61 v' = (i-(gleak*(v-Vl)+gK*(v-vk)+gNa*(v-vna))+eps*(u1-v)/dx)/C+p0*pulse(t-taup) aux longcur=eps*(u1-v)/dx #**************************************************** gNa=gbarNa*(m**3)*h alpham=if (v+54) then (0.32*(V+54)/(1-exp(-(V+54)/4))) else (0.32) betam=if (V+27) then (0.28*(V+27)/(exp((V+27)/5)-1)) else (0.28) alphah=0.128*exp(-(V+50)/18) betah=4/(1+exp(-(V+27)/5)) dm/dt=alpham*(1-m)-betam*m dh/dt=alphah*(1-h)-betah*h #********************************************************** gK=gbarK*(n**4) alphan=if (V+52) then (0.032*(V+52)/(1-exp(-(V+52)/5))) else (0.032) betan=0.5*exp(-(V+57)/40) dn/dt=alphan*(1-n)-betan*n # auxiliary variables # sod is sodium current aux sod=gbarNa*(m**3)*h*(v-vna) # pot is potassium current aux pot=gbarK*(n**4)*(v-vk) #initial conditions init v=-70 init h=1-.000001,m=.000001,n=.000001 par Vna=50,Vk=-100,Vl=-67 par gld=0.1 p Vp=-50, Vsp=9, gnad=0.02, taupna=10 pinfd(V)=1/(1+exp(-(V-Vp)/Vsp)) Inap(V,y)=gnad*y*(V-Vna)/gld pn[1..50]'=(pinfd(u[j])-pn[j])/taupna Ild(V)=V-Vl # cable equation p p[0..50]=0 u1'=((lambda/dx)^2*(u2-2*u1+v)-Ild(u1)-Inap(u1,pn1))/tau +p1*pulse(t-taup) u[2..50]'= ((lambda/dx)^2*(u[j+1]-2*u[j]+u[j-1])-Ild(u[j])-Inap(u[j],pn[j]))/tau +p[j]*pulse(t-taup) u51=(c1+b1*u50/dx)/(a1+b1/dx) par lambda=1,tau=10,dx=.1,c1=0,a1=0,b1=1,c0=0,a0=0,b0=1,eps=.025 pulse(t)=heav(t)*heav(sigma-t) par sigma=.2 par t0=241.3 aux prc=t0-t taup'=0 i u[1..50]=-60 i pn[1..50]=.1 par taur=1,taud=3,thresh=-30,gsyn=.1,Esyn=0 x1'=(-x1+.5*(1+tanh((v-thresh)/3.0)))/taur y1'=(-y1+x1)/taud init x1=0,y1=0 d