COMMENT
%W% %G%
ENDCOMMENT
COMMENT
The non specific current eliminates the electrical effect of the calcium current. To obtain the
electrogenic Na/Ca exchanger, the non specific current should be multiplied by 3/2.
ENDCOMMENT
UNITS {
(mM) = (milli/liter)
(mA) = (milliamp)
(mV) = (millivolt)
(um) = (micron)
(mol) = (1)
PI = (pi) (1)
FARADAY = (faraday) (coulomb)
}
NEURON {
SUFFIX nacaexch
USEION ca READ cao, cai WRITE ica
NONSPECIFIC_CURRENT i
RANGE i,iexch
GLOBAL k, Nai, Nao, E1, E2, c1, c2, e1, e2,s
}
PARAMETER {
cao (mM)
cai (mM)
k = 9.355e-7 (mA/mM4-cm2)
Nai = 9.5710389 (mM)
Nao = 152.43715 (mM)
e1 = 0.3516
e2 = 0.6825
E1
E2
c1
c2
s = 1
}
INITIAL {
c1 = Nai*Nai*Nai
c2 = Nao*Nao*Nao
E1 = e1/26.73
E2 = e2/26.73
}
ASSIGNED {
iexch (mA/cm2)
ica (mA/cm2)
i (mA/cm2)
v (mV)
}
UNITSOFF
BREAKPOINT {
iexch = -k*(cao*c1*exp(E1*(v)) - cai*c2*exp(-E2*(v)))
ica = iexch
i = -s*iexch
}
UNITSON