NEURON {
SUFFIX ab4BK2
USEION ca READ cai
USEION k READ ek WRITE ik
RANGE gbar, g, i
GLOBAL inf_n, tau_n
}
UNITS {
(molar) = (1/liter)
(mM) = (millimolar)
(mV) = (millivolt)
(mA) = (milliamp)
(pS) = (picosiemens)
(um) = (micrometer)
(S) = (siemens)
: B= 0.26 (mM-cm2/mA-ms)
}
PARAMETER {
gbar = 3 (pS/um2)
: inf_n parameters
vhalf_n = -56.5 (mV)
slope_n = 11.8 (mV)
: tau_n parameters
tauA_n = 14.5 (ms)
tauG_n = 0.48 : Left-right bias. range(0,1)
tau0_n = 1 (ms) : minimum tau
: calcium influence on V0.5
bv = 0.003 (mM)
nv = 2
ah = 120 (mV)
: calcium influence on tau
bt = 0.0022 (mM)
nt = 4
th = 140 (ms)
: calcium conc parameters
scale = 1 (1) :scale cai for nanodomain
cai0 = .00005 (mM)
}
ASSIGNED {
v (mV)
celsius (degC)
ek (mV)
ik (mA/cm2)
ica (mA/cm2)
i (mA/cm2)
area (microm2)
g (pS/um2)
inf_n
tau_n (ms)
vh (mV)
ta (ms)
cai (mM)
: cal (mM)
}
:STATE { ca_i (mM) n }
STATE { n }
BREAKPOINT {
SOLVE state METHOD cnexp
g=0
if( n >=0 ) {
g = gbar * n
}
i = g * (v - ek) * (1e-4)
ik = i
}
INITIAL {
rates(v, cai)
n = inf_n
}
DERIVATIVE state {
: ca_i' = -B*(ica*cascale) - (ca_i - ca0)/tau
rates (v, cai0+scale*(cai-cai0))
n' = (inf_n - n) / tau_n
}
PROCEDURE rates (v (mV), cai (mM)) {
vh = vhalf_n + ah /( 1+(cai/bv)^nv ) : Ca shift in v0.5
inf_n = 1 / (1 + exp((v-vh)/-slope_n))
ta = tauA_n + th / ( 1 + (cai/bt)^nt) : Ca shift in tauA
tau_n = tau0_n + 4*ta*sqrt(tauG_n*(1-tauG_n))/(exp(tauG_n*(v - vh)/slope_n)+exp(-(1-tauG_n)*(v - vh)/slope_n))
}