COMMENT
kv.mod
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX kv
USEION k READ ek WRITE ik
RANGE n, h, gk, gbar
RANGE ninf, ntau, hinf, htau
GLOBAL q10, temp, vmin, vmax, v05, za, v05h,zh, Tscale
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
}
PARAMETER {
gbar = 0 (pS/um2)
v (mV)
v05 = -15 (mV)
za = 11 (mV)
v05h = -18 (mV)
zh = -11 (mV)
dt (ms)
celsius (degC)
temp = 33 (degC) : original temp
q10 = 2.3 : temperature sensitivity
Tscale = 10 (degC)
vmin = -120 (mV)
vmax = 100 (mV)
}
ASSIGNED {
ik (mA/cm2)
ek (mV)
gk (pS/um2)
ninf
hinf
ntau (ms)
htau (ms)
}
STATE { n h }
INITIAL {
rates(v)
n = ninf
h = hinf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gk=gbar*n*h
ik = (1e-4)*gk*(v - ek)
}
DERIVATIVE states {
rates(v)
n' = (ninf - n)/ntau
h' = (hinf - h)/htau
}
PROCEDURE rates(vm) {
LOCAL qt
qt=q10^((celsius-temp)/Tscale)
ninf = 1/(1 + exp(-(vm - v05)/za))
ntau = (0.31+1492/((vm+23.5)^2+565)) :/qt
hinf = 1/(1 + exp(-(vm - v05h)/zh))
htau=300
}