: Sodium chanel from
: Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones
: Lu-Yang Wang, Li Gan, Ian D. Forsythe and Leonard K. Kaczmarek
: J. Physiol (1998), 501.9, pp. 183-194
NEURON {
SUFFIX NaCh
USEION na READ ena WRITE ina
RANGE gbar, g, ina
GLOBAL minf, mtau, hinf, htau, am, bm, ah, bh
}
: area in paper is 1000 (um2) so divide our density parameters by 10
UNITS {
(mV) = (millivolt)
(S) = (mho)
(mA) = (milliamp)
}
PARAMETER {
gbar = .05 (S/cm2) : .5 (uS)
gamma = .1
kam = 76.4 (/ms)
eam = .037 (/mV)
:kbm = .0381 (/ms) : typo in paper
kbm = 6.930852 (/ms) : personal communication from L. Kaczmarek
ebm = -.043 (/mV)
kah = .00013 (/ms)
eah = -.1216 (/mV)
kbh = 1.999 (/ms)
ebh = .0384 (/mV)
}
ASSIGNED {
v (mV)
ena (mV)
ina (mA/cm2)
minf
mtau (ms)
hinf
htau (ms)
am (/ms)
bm (/ms)
ah (/ms)
bh (/ms)
}
STATE {
m h
}
INITIAL {
rates(v)
m = minf
h = hinf
}
BREAKPOINT {
SOLVE state METHOD cnexp
ina = gbar*m^3*h*(v - ena)
}
DERIVATIVE state {
rates(v)
m' = (minf - m)/mtau
h' = (hinf - h)/htau
}
PROCEDURE rates(v(mV)) {
am = kam*exp(eam*v)
bm = kbm*exp(ebm*v)
ah = kah*exp(eah*v)
bh = kbh*exp(ebh*v)
minf = am/(am + bm)
mtau = 1/(am + bm)
hinf = ah/(ah + bh)
htau = 1/(ah + bh)
}