NEURON Mod Files from the Paper
Miceli et al, Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of Kv7.2 potassium channel subunits, PNAS 2013 Feb 25. [Epub ahead of print]
In this paper, functional studies revealed that in homomeric or heteromeric configuration with KV7.2 and/or KV7.3 subunits, R213W and R213Q mutations markedly destabilized the open state, causing a dramatic decrease in channel voltage sensitivity. Modeling these channels in CA1 hippocampal pyramidal cells revealed that both mutations increased cell firing frequency, with the R213Q mutation prompting more dramatic functional changes compared with the R213W mutation. The fig4a.hoc
reproduces the traces shown in Fig. 4a of the paper.
nrnivmodl
nrngui fig6a.hoc
mknrndll
command.fig6a.hoc
will open the simulation window.Once the simulation is started you can select the desired simulation.
Questions on how to use this model should be directed to michele.migliore@cnr.it
Date | Update Details |
---|---|
20150524 | Update from Ted Carnevale: In cad.mod , fixed ca initialization by inserting cai = ca into the INITIAL block. Changed integration method from euler to derivimplicit , which is appropriate for simple ion accumulation mechanisms. See Integration methods for SOLVE statements. |
20250525 | Readme reformatted as markdown. |