create neutral /xout function make_control create xform /xout/control [10,10,250,250] create xlabel /xout/control/label -hgeom 30 -bg cyan -label "THIS IS A CONTROL PANEL" create xbutton /xout/control/RESET -wgeom 33% -script reset create xbutton /xout/control/RUN -xgeom 0:RESET -ygeom 0:label -wgeom 33% \ -script step_tmax create xbutton /xout/control/QUIT -xgeom 0:RUN -ygeom 0:label -wgeom 34% \ -script quit create xdialog /xout/control/time -label "Simulation time" \ -value {sim_time} -script "set_sim_time <widget>" create xdialog /xout/control/Inj -label "Injection (nA)" \ -value 0.0 -script "set_inject <widget>" xshow /xout/control end function make_Vmgraph create xform /xout/data [270,10,700,225] create xlabel /xout/data/label -hgeom 10% -label "Membrane Potential" create xgraph /xout/data/voltage -hgeom 90% setfield ^ XUnits sec YUnits mV setfield ^ xmax {sim_time} ymin -0.080 ymax 0.060 // setfield ^ xmax {sim_time} ymin -0.15 ymax 0.1 useclock /xout/data 1 xshow /xout/data end function make_currgraph create xform /xout/curr [270,270,700,225] create xlabel /xout/curr/label -hgeom 10% "Current" create xgraph /xout/curr/current -hgeom 90% -wgeom 50% setfield ^ XUnits msec YUnits nA setfield ^ xmin {10} xmax {15} ymin 0 ymax 1 cdxmin 100 create xgraph /xout/curr/conc -xgeom 0:current -ygeom 0:label -hgeom 90% -wgeom 50% setfield ^ XUnits sec YUnits M setfield ^ xmax {sim_time} ymin 0.0 ymax 1.0 useclock /cout/curr 1 xshow /xout/curr end function step_tmax step {sim_time} -t end function set_inject(dialog) str dialog setfield /neuron/soma inject {{getfield {dialog} value}*1e-9} end function set_sim_time(dialog) str dialog,plot sim_time={{getfield {dialog} value}} foreach plot ({el /xout/##[TYPE=xgraph]}) setfield {plot} xmax {sim_time} end end // FILE OUTPUT // Voltages create asc_file /out-v setfield /out-v filename out-v.dat flush 1 leave_open 1 useclock /out-v 0.1 // Voltages in a primary dendritic comp create asc_file /out-v-pd setfield /out-v-pd filename out-v-pd.dat flush 1 leave_open 1 useclock /out-v-pd 0.1 // Voltages in a tertiary dendritic comp create asc_file /out-v-td setfield /out-v-td filename out-v-td.dat flush 1 leave_open 1 useclock /out-v-td 0.1 // Currents create asc_file /out-c setfield /out-c filename out-c.dat flush 1 leave_open 1 useclock /out-c 0.1 // Currents in a primary dendritic comp create asc_file /out-c-pd setfield /out-c-pd filename out-c-pd.dat flush 1 leave_open 1 useclock /out-c-pd 0.1 // Currents in a tertiary dendritic comp create asc_file /out-c-td setfield /out-c-td filename out-c-td.dat flush 1 leave_open 1 useclock /out-c-td 0.1 // Activations create asc_file /na-act-inact-soma setfield /na-act-inact-soma filename na-act-inact-soma.dat flush 1 leave_open 1 useclock /na-act-inact-soma 0.1 create asc_file /ka-act-inact-soma setfield /ka-act-inact-soma filename ka-act-inact-soma.dat flush 1 leave_open 1 useclock /ka-act-inact-soma 0.1 create asc_file /na-act-inact-is setfield /na-act-inact-is filename na-act-inact-is.dat flush 1 leave_open 1 useclock /na-act-inact-is 0.1 make_control make_Vmgraph make_currgraph // make_Cagraph // Plot voltages addmsg /neuron/soma /xout/data/voltage PLOT Vm *neuron1 *red // addmsg /neuron/is /xout/data/voltage PLOT Vm *Iseg *blue // addmsg /neuron/soma /out-v SAVE Vm // Plot Na conc addmsg /neuron/soma/fshNa/Na_slow_pool /xout/curr/conc PLOT Ca *slowNaPool(soma) *red // Plot currents // Spiking and spiking-coupled addmsg /neuron/soma/fshNa /xout/curr/current PLOT Ik *Na *red addmsg /neuron/soma/Kt /xout/curr/current PLOT Ik *Kt *blue addmsg /neuron/soma/Ks /xout/curr/current PLOT Ik *Ks *black addmsg /neuron/soma/KNa_fast /xout/curr/current PLOT Ik *KNa_fast *yellow // addmsg /neuron/is/fshNa-is /xout/curr/current PLOT Ik *Na *red // addmsg /neuron/is/Kt /xout/curr/current PLOT Ik *Ka *blue // AHP related addmsg /neuron/soma/Ca_N /xout/curr/current PLOT Ik *Ca_N *brown addmsg /neuron/soma/Ca_L /xout/curr/current PLOT Ik *Ca_L *green addmsg /neuron/soma/KCa_N /xout/curr/current PLOT Ik *KCa_N *orange addmsg /neuron/soma/Ca_LVA /xout/curr/current PLOT Ik *Ca_LVA *purple addmsg /neuron/soma/KNa_slow /xout/curr/current PLOT Ik *KNa_slow *red // NMDA related // addmsg /neuron/soma/NMDA /xout/curr/current PLOT Ik *NMDA *white // addmsg /neuron/soma/Ca_NMDA /xout/curr/current PLOT Ik *Ca_NMDA *purple // addmsg /neuron/soma/KCa_NMDA /xout/curr/current PLOT Ik *KCa_NMDA *cyan // Write currents to file // AP related // addmsg /neuron/soma/Kt /out-c SAVE Ik // addmsg /neuron/soma/fshNa /out-c SAVE Ik // addmsg /neuron/soma/Ks /out-c SAVE Ik // addmsg /neuron/soma/KNa_fast /out-c SAVE Ik // Slow // addmsg /neuron/soma/Ca_N /out-c SAVE Ik // addmsg /neuron/soma/KCa_N /out-c SAVE Ik // addmsg /neuron/soma/Ca_L /out-c SAVE Ik // addmsg /neuron/soma/NMDA /out-c SAVE Ik // addmsg /neuron/soma/Ca_NMDA /out-c SAVE Ik // addmsg /neuron/soma/KCa_NMDA /out-c SAVE Ik // addmsg /neuron/soma/KNa_slow /out-c SAVE Ik