/* Created by Language version: 7.7.0 */
/* NOT VECTORIZED */
#define NRN_VECTORIZED 0
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
 
#if METHOD3
extern int _method3;
#endif

#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
 
#define nrn_init _nrn_init__kca
#define _nrn_initial _nrn_initial__kca
#define nrn_cur _nrn_cur__kca
#define _nrn_current _nrn_current__kca
#define nrn_jacob _nrn_jacob__kca
#define nrn_state _nrn_state__kca
#define _net_receive _net_receive__kca 
#define rates rates__kca 
#define states states__kca 
 
#define _threadargscomma_ /**/
#define _threadargsprotocomma_ /**/
#define _threadargs_ /**/
#define _threadargsproto_ /**/
 	/*SUPPRESS 761*/
	/*SUPPRESS 762*/
	/*SUPPRESS 763*/
	/*SUPPRESS 765*/
	 extern double *getarg();
 static double *_p; static Datum *_ppvar;
 
#define t nrn_threads->_t
#define dt nrn_threads->_dt
#define gbar _p[0]
#define gk _p[1]
#define ninf _p[2]
#define ntau _p[3]
#define n _p[4]
#define cai _p[5]
#define a _p[6]
#define b _p[7]
#define ik _p[8]
#define ek _p[9]
#define Dn _p[10]
#define _g _p[11]
#define _ion_ek	*_ppvar[0]._pval
#define _ion_ik	*_ppvar[1]._pval
#define _ion_dikdv	*_ppvar[2]._pval
#define _ion_cai	*_ppvar[3]._pval
 
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
 
#if defined(__cplusplus)
extern "C" {
#endif
 static int hoc_nrnpointerindex =  -1;
 /* external NEURON variables */
 extern double celsius;
 /* declaration of user functions */
 static void _hoc_rates(void);
 static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
 
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif

 extern void _nrn_setdata_reg(int, void(*)(Prop*));
 static void _setdata(Prop* _prop) {
 _p = _prop->param; _ppvar = _prop->dparam;
 }
 static void _hoc_setdata() {
 Prop *_prop, *hoc_getdata_range(int);
 _prop = hoc_getdata_range(_mechtype);
   _setdata(_prop);
 hoc_retpushx(1.);
}
 /* connect user functions to hoc names */
 static VoidFunc hoc_intfunc[] = {
 "setdata_kca", _hoc_setdata,
 "rates_kca", _hoc_rates,
 0, 0
};
 /* declare global and static user variables */
#define Rb Rb_kca
 double Rb = 0.02;
#define Ra Ra_kca
 double Ra = 0.01;
#define caix caix_kca
 double caix = 1;
#define q10 q10_kca
 double q10 = 2.3;
#define tadj tadj_kca
 double tadj = 0;
#define temp temp_kca
 double temp = 23;
#define vmax vmax_kca
 double vmax = 100;
#define vmin vmin_kca
 double vmin = -120;
 /* some parameters have upper and lower limits */
 static HocParmLimits _hoc_parm_limits[] = {
 0,0,0
};
 static HocParmUnits _hoc_parm_units[] = {
 "Ra_kca", "/ms",
 "Rb_kca", "/ms",
 "temp_kca", "degC",
 "vmin_kca", "mV",
 "vmax_kca", "mV",
 "gbar_kca", "pS/um2",
 "gk_kca", "pS/um2",
 "ntau_kca", "ms",
 0,0
};
 static double delta_t = 1;
 static double n0 = 0;
 static double v = 0;
 /* connect global user variables to hoc */
 static DoubScal hoc_scdoub[] = {
 "caix_kca", &caix_kca,
 "Ra_kca", &Ra_kca,
 "Rb_kca", &Rb_kca,
 "temp_kca", &temp_kca,
 "q10_kca", &q10_kca,
 "vmin_kca", &vmin_kca,
 "vmax_kca", &vmax_kca,
 "tadj_kca", &tadj_kca,
 0,0
};
 static DoubVec hoc_vdoub[] = {
 0,0,0
};
 static double _sav_indep;
 static void nrn_alloc(Prop*);
static void  nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
 static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void  nrn_jacob(_NrnThread*, _Memb_list*, int);
 
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
 
#define _cvode_ieq _ppvar[4]._i
 static void _ode_matsol_instance1(_threadargsproto_);
 /* connect range variables in _p that hoc is supposed to know about */
 static const char *_mechanism[] = {
 "7.7.0",
"kca",
 "gbar_kca",
 0,
 "gk_kca",
 "ninf_kca",
 "ntau_kca",
 0,
 "n_kca",
 0,
 0};
 static Symbol* _k_sym;
 static Symbol* _ca_sym;
 
extern Prop* need_memb(Symbol*);

static void nrn_alloc(Prop* _prop) {
	Prop *prop_ion;
	double *_p; Datum *_ppvar;
 	_p = nrn_prop_data_alloc(_mechtype, 12, _prop);
 	/*initialize range parameters*/
 	gbar = 10;
 	_prop->param = _p;
 	_prop->param_size = 12;
 	_ppvar = nrn_prop_datum_alloc(_mechtype, 5, _prop);
 	_prop->dparam = _ppvar;
 	/*connect ionic variables to this model*/
 prop_ion = need_memb(_k_sym);
 nrn_promote(prop_ion, 0, 1);
 	_ppvar[0]._pval = &prop_ion->param[0]; /* ek */
 	_ppvar[1]._pval = &prop_ion->param[3]; /* ik */
 	_ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dikdv */
 prop_ion = need_memb(_ca_sym);
 nrn_promote(prop_ion, 1, 0);
 	_ppvar[3]._pval = &prop_ion->param[1]; /* cai */
 
}
 static void _initlists();
  /* some states have an absolute tolerance */
 static Symbol** _atollist;
 static HocStateTolerance _hoc_state_tol[] = {
 0,0
};
 static void _update_ion_pointer(Datum*);
 extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);

 void _kca_reg() {
	int _vectorized = 0;
  _initlists();
 	ion_reg("k", -10000.);
 	ion_reg("ca", -10000.);
 	_k_sym = hoc_lookup("k_ion");
 	_ca_sym = hoc_lookup("ca_ion");
 	register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 0);
 _mechtype = nrn_get_mechtype(_mechanism[1]);
     _nrn_setdata_reg(_mechtype, _setdata);
     _nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
 #if NMODL_TEXT
  hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
  hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
  hoc_register_prop_size(_mechtype, 12, 5);
  hoc_register_dparam_semantics(_mechtype, 0, "k_ion");
  hoc_register_dparam_semantics(_mechtype, 1, "k_ion");
  hoc_register_dparam_semantics(_mechtype, 2, "k_ion");
  hoc_register_dparam_semantics(_mechtype, 3, "ca_ion");
  hoc_register_dparam_semantics(_mechtype, 4, "cvodeieq");
 	hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
 	hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
 	hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
 	ivoc_help("help ?1 kca /Users/landauland/Dropbox/SabatiniLab/neuron-modeling/smithAdaptation/mod.files/x86_64/kca.mod\n");
 hoc_register_limits(_mechtype, _hoc_parm_limits);
 hoc_register_units(_mechtype, _hoc_parm_units);
 }
 static double _znexp ;
static int _reset;
static char *modelname = "";

static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rates(double);
 
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
 static int _slist1[1], _dlist1[1];
 static int states(_threadargsproto_);
 
/*CVODE*/
 static int _ode_spec1 () {_reset=0;
 {
   rates ( _threadargscomma_ cai ) ;
   Dn = ( ninf - n ) / ntau ;
   }
 return _reset;
}
 static int _ode_matsol1 () {
 rates ( _threadargscomma_ cai ) ;
 Dn = Dn  / (1. - dt*( ( ( ( - 1.0 ) ) ) / ntau )) ;
  return 0;
}
 /*END CVODE*/
 static int states () {_reset=0;
 {
   rates ( _threadargscomma_ cai ) ;
    n = n + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / ntau)))*(- ( ( ( ninf ) ) / ntau ) / ( ( ( ( - 1.0 ) ) ) / ntau ) - n) ;
   }
  return 0;
}
 
static int  rates (  double _lcai ) {
   a = Ra * pow( _lcai , caix ) ;
   b = Rb ;
   tadj = pow( q10 , ( ( celsius - temp ) / 10.0 ) ) ;
   ntau = 1.0 / tadj / ( a + b ) ;
   ninf = a / ( a + b ) ;
    return 0; }
 
static void _hoc_rates(void) {
  double _r;
   _r = 1.;
 rates (  *getarg(1) );
 hoc_retpushx(_r);
}
 
static int _ode_count(int _type){ return 1;}
 
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
   Datum* _thread;
   Node* _nd; double _v; int _iml, _cntml;
  _cntml = _ml->_nodecount;
  _thread = _ml->_thread;
  for (_iml = 0; _iml < _cntml; ++_iml) {
    _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
    _nd = _ml->_nodelist[_iml];
    v = NODEV(_nd);
  ek = _ion_ek;
  cai = _ion_cai;
     _ode_spec1 ();
  }}
 
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) { 
 	int _i; _p = _pp; _ppvar = _ppd;
	_cvode_ieq = _ieq;
	for (_i=0; _i < 1; ++_i) {
		_pv[_i] = _pp + _slist1[_i];  _pvdot[_i] = _pp + _dlist1[_i];
		_cvode_abstol(_atollist, _atol, _i);
	}
 }
 
static void _ode_matsol_instance1(_threadargsproto_) {
 _ode_matsol1 ();
 }
 
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
   Datum* _thread;
   Node* _nd; double _v; int _iml, _cntml;
  _cntml = _ml->_nodecount;
  _thread = _ml->_thread;
  for (_iml = 0; _iml < _cntml; ++_iml) {
    _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
    _nd = _ml->_nodelist[_iml];
    v = NODEV(_nd);
  ek = _ion_ek;
  cai = _ion_cai;
 _ode_matsol_instance1(_threadargs_);
 }}
 extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
 static void _update_ion_pointer(Datum* _ppvar) {
   nrn_update_ion_pointer(_k_sym, _ppvar, 0, 0);
   nrn_update_ion_pointer(_k_sym, _ppvar, 1, 3);
   nrn_update_ion_pointer(_k_sym, _ppvar, 2, 4);
   nrn_update_ion_pointer(_ca_sym, _ppvar, 3, 1);
 }

static void initmodel() {
  int _i; double _save;_ninits++;
 _save = t;
 t = 0.0;
{
  n = n0;
 {
   rates ( _threadargscomma_ cai ) ;
   n = ninf ;
   }
  _sav_indep = t; t = _save;

}
}

static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
    _ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
 _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
  if (use_cachevec) {
    _v = VEC_V(_ni[_iml]);
  }else
#endif
  {
    _nd = _ml->_nodelist[_iml];
    _v = NODEV(_nd);
  }
 v = _v;
  ek = _ion_ek;
  cai = _ion_cai;
 initmodel();
 }}

static double _nrn_current(double _v){double _current=0.;v=_v;{ {
   gk = tadj * gbar * n ;
   ik = ( 1e-4 ) * gk * ( v - ek ) ;
   }
 _current += ik;

} return _current;
}

static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
    _ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
 _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
  if (use_cachevec) {
    _v = VEC_V(_ni[_iml]);
  }else
#endif
  {
    _nd = _ml->_nodelist[_iml];
    _v = NODEV(_nd);
  }
  ek = _ion_ek;
  cai = _ion_cai;
 _g = _nrn_current(_v + .001);
 	{ double _dik;
  _dik = ik;
 _rhs = _nrn_current(_v);
  _ion_dikdv += (_dik - ik)/.001 ;
 	}
 _g = (_g - _rhs)/.001;
  _ion_ik += ik ;
#if CACHEVEC
  if (use_cachevec) {
	VEC_RHS(_ni[_iml]) -= _rhs;
  }else
#endif
  {
	NODERHS(_nd) -= _rhs;
  }
 
}}

static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
    _ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
 _p = _ml->_data[_iml];
#if CACHEVEC
  if (use_cachevec) {
	VEC_D(_ni[_iml]) += _g;
  }else
#endif
  {
     _nd = _ml->_nodelist[_iml];
	NODED(_nd) += _g;
  }
 
}}

static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
    _ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
for (_iml = 0; _iml < _cntml; ++_iml) {
 _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
 _nd = _ml->_nodelist[_iml];
#if CACHEVEC
  if (use_cachevec) {
    _v = VEC_V(_ni[_iml]);
  }else
#endif
  {
    _nd = _ml->_nodelist[_iml];
    _v = NODEV(_nd);
  }
 v=_v;
{
  ek = _ion_ek;
  cai = _ion_cai;
 { error =  states();
 if(error){fprintf(stderr,"at line 76 in file kca.mod:\n        SOLVE states METHOD cnexp\n"); nrn_complain(_p); abort_run(error);}
 } }}

}

static void terminal(){}

static void _initlists() {
 int _i; static int _first = 1;
  if (!_first) return;
 _slist1[0] = &(n) - _p;  _dlist1[0] = &(Dn) - _p;
_first = 0;
}

#if NMODL_TEXT
static const char* nmodl_filename = "/Users/landauland/Dropbox/SabatiniLab/neuron-modeling/smithAdaptation/mod.files/kca.mod";
static const char* nmodl_file_text = 
  "\n"
  "COMMENT\n"
  "26 Ago 2002 Modification of original channel to allow variable time step and to correct an initialization error.\n"
  "    Done by Michael Hines(michael.hines@yale.e) and Ruggero Scorcioni(rscorcio@gmu.edu) at EU Advance Course in Computational Neuroscience. Obidos, Portugal\n"
  "\n"
  "kca.mod\n"
  "\n"
  "Calcium-dependent potassium channel\n"
  "Based on\n"
  "Pennefather (1990) -- sympathetic ganglion cells\n"
  "taken from\n"
  "Reuveni et al (1993) -- neocortical cells\n"
  "\n"
  "Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu\n"
  "	\n"
  "ENDCOMMENT\n"
  "\n"
  "INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}\n"
  "\n"
  "NEURON {\n"
  "	SUFFIX kca\n"
  "	USEION k READ ek WRITE ik\n"
  "	USEION ca READ cai\n"
  "	RANGE n, gk, gbar\n"
  "	RANGE ninf, ntau\n"
  "	GLOBAL Ra, Rb, caix\n"
  "	GLOBAL q10, temp, tadj, vmin, vmax\n"
  "}\n"
  "\n"
  "UNITS {\n"
  "	(mA) = (milliamp)\n"
  "	(mV) = (millivolt)\n"
  "	(pS) = (picosiemens)\n"
  "	(um) = (micron)\n"
  "} \n"
  "\n"
  "PARAMETER {\n"
  "	gbar = 10   	(pS/um2)	: 0.03 mho/cm2\n"
  "	v 		(mV)\n"
  "	cai  		(mM)\n"
  "	caix = 1	\n"
  "									\n"
  "	Ra   = 0.01	(/ms)		: max act rate  \n"
  "	Rb   = 0.02	(/ms)		: max deact rate \n"
  "\n"
  "	dt		(ms)\n"
  "	celsius		(degC)\n"
  "	temp = 23	(degC)		: original temp 	\n"
  "	q10  = 2.3			: temperature sensitivity\n"
  "\n"
  "	vmin = -120	(mV)\n"
  "	vmax = 100	(mV)\n"
  "} \n"
  "\n"
  "\n"
  "ASSIGNED {\n"
  "	a		(/ms)\n"
  "	b		(/ms)\n"
  "	ik 		(mA/cm2)\n"
  "	gk		(pS/um2)\n"
  "	ek		(mV)\n"
  "	ninf\n"
  "	ntau 		(ms)	\n"
  "	tadj\n"
  "}\n"
  " \n"
  "\n"
  "STATE { n }\n"
  "\n"
  "INITIAL { \n"
  "	rates(cai)\n"
  "	n = ninf\n"
  "}\n"
  "\n"
  "BREAKPOINT {\n"
  "        SOLVE states METHOD cnexp\n"
  "	gk = tadj*gbar*n\n"
  "	ik = (1e-4) * gk * (v - ek)\n"
  "} \n"
  "\n"
  "LOCAL nexp\n"
  "\n"
  "DERIVATIVE states {   :Computes state variable n \n"
  "        rates(cai)      :             at the current v and dt.\n"
  "        n' =  (ninf-n)/ntau\n"
  "\n"
  "}\n"
  "\n"
  "PROCEDURE rates(cai(mM)) {  \n"
  "\n"
  "        \n"
  "\n"
  "        a = Ra * cai^caix\n"
  "        b = Rb\n"
  "\n"
  "        tadj = q10^((celsius - temp)/10)\n"
  "\n"
  "        ntau = 1/tadj/(a+b)\n"
  "	ninf = a/(a+b)\n"
  "\n"
  " \n"
  ":        tinc = -dt * tadj\n"
  ":        nexp = 1 - exp(tinc/ntau)\n"
  "}\n"
  "\n"
  "\n"
  "\n"
  "\n"
  "\n"
  "\n"
  "\n"
  "\n"
  "\n"
  "\n"
  "\n"
  ;
#endif