NEURON { POINT_PROCESS GABAB1 }
: Simple synaptic mechanism derived for first order kinetics of
: binding of transmitter to postsynaptic receptors.
:
: GABA SYNAPSE (GABA-B receptors)
:
: Parameters estimated from patch clamp recordings of GABAB PSP's in
: rat hippocampal slices (Otis et al, J. Physiol. 463: 391-407, 1993)
: and sharp electrode recordings in hippocampal pyramidal cells
: (Solis & Nicoll, J. Neurosci. 12: 3466-3472, 1992).
:
: To account for the time course of the GABAB IPSP with a first order
: kinetics, it is assumed that the transmitter stays for 150 ms in the
: synaptic cleft. This is very unrealistic, but it provides reasonable
: summation of PSP's.
:
: A. Destexhe , The Salk Institute, May 1993.
PARAMETER {
Cmax = 1 (mM) : max transmitter concentration
Cdur = 150 (ms) : transmitter duration (rising phase)
Alpha = 0.01 (/ms mM) : forward (binding) rate
Beta = 0.005 (/ms) : backward (unbinding) rate
Erev = -95 (mV) : reversal potential (potassium)
Prethresh = 0 : voltage level nec for release
Deadtime = 1 (ms) : mimimum time between release events
gmax (umho) : maximum conductance
}
INCLUDE "synq.inc"
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