TITLE HH style Ih channel for RGCs
:
: David Tsai, May 2012
: Started from kinetics of McCormick, Pape 1990
:
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
eh (mV)
celsius (degC)
ghbar=0.00003 (mho/cm2)
vhalft=-20 (mV)
a0t=0.0005 (/ms)
zetat=0.2 (1)
gmt=.05 (1)
q10=4.5
}
NEURON {
SUFFIX ih
NONSPECIFIC_CURRENT i
RANGE ghbar, eh
GLOBAL linf,taul
}
STATE {
l
}
ASSIGNED {
i (mA/cm2)
linf
taul
}
INITIAL {
rate(v)
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
i = ghbar*l*(v-eh)
}
FUNCTION alpt(v(mV)) {
alpt = exp(zetat*(v-vhalft))
}
FUNCTION bett(v(mV)) {
bett = exp(zetat*gmt*(v-vhalft))
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rate(v)
l' = (linf - l)/taul
}
PROCEDURE rate(v (mV)) { :callable from hoc
LOCAL qt
qt=q10^((celsius-36)/10)
linf = 1/(1+ exp((v+75)/5.5))
taul = bett(v)/(qt*a0t*(1+alpt(v)))
}