TITLE Int1 cell
:
NEURON {
SUFFIX int1
USEION K WRITE iK VALENCE 1
USEION Na WRITE iNa VALENCE 1
USEION h WRITE ih VALENCE 1
NONSPECIFIC_CURRENT iL
GLOBAL gL,gbarNa ,gbarK,gbarh,eL,eK, eNa,eh
}
UNITS {
(mA) = (milliamp)
(nA) = (nanoamp)
(mV) = (millivolt)
(um) = (micron)
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
v (mV)
dt = 0.1 (ms)
gbarh = 0.000 (mho/cm2)
gbarNa = 0.0035 (mho/cm2)
gbarK = 0.006 (mho/cm2)
gL = 0.00000729 (mho/cm2)
eh = -20 (mV)
eNa = 45 (mV)
eK = -80 (mV)
eL = -30 (mV)
}
STATE { Kon Koff Nahon Nahoff hon hoff
}
ASSIGNED {
ih (mA/cm2)
iNa (mA/cm2)
iK (mA/cm2)
iL (mA/cm2)
}
BREAKPOINT {
SOLVE ssss METHOD sparse
ih = gbarh*hoff*(v-eh)
iNa = gbarNa*minf(v)*minf(v)*minf(v)*Nahoff*(v-eNa)
iK = gbarK*Koff*Koff*Koff*Koff*(v-eK)
iL = gL*(v - eL)
}
KINETIC ssss {
~ hon <-> hoff (hminf(v)/tauhm(v),(1-hminf(v))/tauhm(v))
~ Nahon <-> Nahoff (hinf(v)/tauh(v),(1-hinf(v))/tauh(v))
~ Kon <-> Koff (kinf(v)/tauk(v),(1-kinf(v))/tauk(v))
}
INITIAL {
hon = hminf(v)
hoff = 1 - hminf(v)
Nahon = hinf(v)
Nahoff = 1 - Nahon
Kon = kinf(v)
Koff = 1 - Kon
}
FUNCTION hminf(v){
hminf = 1/(1+exp(2*(v+65)))
}
FUNCTION minf(v){
minf = 1/(1+exp(-0.08*(v+26)))
}
FUNCTION hinf(v){
hinf = 1/(1+exp(0.13*(v+38)))
}
FUNCTION kinf(v){
kinf = 1/(1+exp(-0.045*(v+25)))
}
FUNCTION tauhm(v)(ms){
tauhm = 200+2500/(1+exp(2*(v+65)))
}
FUNCTION tauh(v)(ms){
tauh = 5/(1+exp(-0.12*(v+67)))
}
FUNCTION tauk(v(mV))(ms){
tauk = (4 + 150/(1+exp(0.065*(v+30))))
}