//mitral-granule reciprocal synapse
//src, target
// assume src,target unique
func syn_gid() {local i
if ($1 < num_mitral) { // target is granule
i = ($2 * num_mitral + $1 + 1 + ncell) * 100 + 1
}else{ // target is mitral
i = ($1 * num_mitral + $2 + 1 + ncell) * 100
}
return i
}
// gid, &mitral, &granule, &is_m2g
proc gid2mg() {local i, m, g, m2g
m2g = $1%2
i = $1 - m2g
i /=100
i -= ncell + 1
m = i%num_mitral
i -= m
g = i/num_mitral - num_mitral
$&2 = m
$&3 = g
$&4 = m2g
}
// imitral, igranule, target_is_granule
proc test_gid2mg() {local gid, m, g, is_m2g
if ($3 == 0) {
gid = syn_gid($2+num_mitral, $1)
}else{
gid = syn_gid($1, $2+num_mitral)
}
gid2mg(gid, &m, &g, &is_m2g)
printf("gid2mg gid=%g m=%d g=%g is_m2g=%g\n", gid, m, g, is_m2g)
}
begintemplate MGRS
public md, gd, md_gid, gd_gid, clear, complete
public fi, ampanmda, mitral, granule, mitral_gid, granule_gid
public md2ampanmda, gd2fi, spine
public fi_exists, ampa_exists, mexist, gexist
public sm, sg, wm, wg, set_sm, set_sg, set_wm, set_wg, ws_str, ws_str_normalized
public pr
external pc, pnm, syn_gid, fi_gmax, fi_tau1, fi_tau2, ampanmda_gmax
external ncell, num_mitral //, nil,amp, rel, inh,synst, nmdafactor
external gid2piece, piecegid
objref mitral, granule
objref md2ampanmda, gd2fi
objref ampanmda, fi, md, gd, spine
objref this, nil, ws_str_
strdef tstr
proc clear() {
objref md2ampanmda, gd2fi
objref ampanmda, fi, md, gd
objref mitral, granule, spine
}
proc init() {
// if $7 == 1 then create fi and ampamda and put in cas
ws_str_ = new String()
mitral_gid = $1
granule_gid = $4
mexist = piecegid(mitral_gid) >= 0
gexist = piecegid(granule_gid) >= 0
md_gid = syn_gid(granule_gid, mitral_gid)
gd_gid = syn_gid(mitral_gid, granule_gid)
mitral = gid2piece(mitral_gid)
granule = gid2piece(granule_gid)
if (mexist) if (section_exists($s2, mitral)) {
// print mitral
create_syn("{mitral.%s { fi = new FastInhib(%-10.20g )}}",$s2, $3)
create_syn("{mitral.%s { md = new ThreshDetect(%-10.20g)}}",$s2, $3)
pc.set_gid2node(md_gid, pc.id)
pc.cell(md_gid, new NetCon(md, nil), 1)
fi.gmax=fi_gmax
fi.tau1=fi_tau1
fi.tau2=fi_tau2
}
if (gexist) {
spine = new GranuleSpine()
create_syn("{granule.%s { connect spine.neck(0), (%-10.20g) }}", $s5, $6)
spine.head { ampanmda = new AmpaNmda(0.5) }
spine.head { gd = new ThreshDetect(0.5)}
pc.set_gid2node(gd_gid, pc.id)
pc.cell(gd_gid, new NetCon(gd, nil), 1)
ampanmda.gmax=ampanmda_gmax //default is 2
}
// print pnm.myid, this, mexist, gexist
if ($7 == 1) { // for showing synapses and weights when cells do not exist
complete()
}
update_netcon()
}
proc complete() {
if (object_id(fi) == 0) {
fi = new FastInhib(0.5)
}
if (object_id(ampanmda) == 0) {
ampanmda = new AmpaNmda(0.5)
}
update_netcon()
}
proc update_netcon() {
if (object_id(ampanmda)) {
// print pnm.myid, this, mitral_gid, granule_gid
// print pnm.myid, this, md_gid,gd_gid
if (object_id(md2ampanmda) == 0) {
md2ampanmda = pc.gid_connect(md_gid, ampanmda)
}
// print pnm.myid, this, md2ampanmda,
ampanmda.mgid = mitral_gid
ampanmda.ggid = granule_gid
ampanmda.srcgid = md_gid
}
if (object_id(fi)) {
// print pnm.myid, this, mitral_gid, granule_gid
// print pnm.myid, this, md_gid,gd_gid
if (object_id(gd2fi) == 0) {
gd2fi = pc.gid_connect(gd_gid, fi )
}
// print pnm.myid, this, gd2fi
fi.mgid = mitral_gid
fi.ggid = granule_gid
fi.srcgid = gd_gid
}
// print pnm.myid, this, mitral_gid, granule_gid, mitral, granule
if (object_id(md2ampanmda)) {
md2ampanmda.weight = 1 // normalized
md2ampanmda.delay = 1
}
if (object_id(gd2fi)) {
gd2fi.weight = 1 // normalized
gd2fi.delay = 1
}
}
proc create_syn() {
sprint(tstr, $s1, $s2, $3)
execute(tstr, this)
}
func fi_exists() {
return (fi != nil)
}
func ampa_exists() {
return (ampanmda != nil)
}
proc pr() {local x localobj s
s = new String()
if (object_id(md)) {
x = md.get_loc()
sprint(s.s, "%s(%g) %d --- ", secname(), x, mitral_gid)
pop_section()
}else{
sprint(s.s, "%27d --- ", mitral_gid)
}
if (object_id(gd)) {
x = gd.get_loc()
sprint(s.s, "%s%d %s(%g)", s.s, granule_gid, secname(), x)
pop_section()
}else{
sprint(s.s, "%s%d", s.s, granule_gid)
}
printf("%d %s\n", pnm.myid, s.s)
}
//returns volatile String in proper wsfile format
// srcid tarid s w
// may be one line or two, no trailing newline
obfunc ws_str() {
if (object_id(gd2fi)) {
if (object_id(md2ampanmda)) {
sprint(ws_str_.s, "%d %d %g %g\n%d %d %g %g",\
granule_gid, mitral_gid, sm(), wm(),\
mitral_gid, granule_gid, sg(), wg())
}else{
sprint(ws_str_.s, "%d %d %g %g",\
granule_gid, mitral_gid, sm(), wm())
}
}else if (object_id(md2ampanmda)) {
sprint(ws_str_.s, "%d %d %g %g", mitral_gid, granule_gid, sg(), wg())
}else{
ws_str_.s = ""
}
return ws_str_
}
obfunc ws_str_normalized() {
if (object_id(gd2fi)) {
if (object_id(md2ampanmda)) {
sprint(ws_str_.s, "%d %d %g %g\n%d %d %g %g",\
granule_gid, mitral_gid, sm(), wm_normalized(),\
mitral_gid, granule_gid, sg(), wg_normalized())
}else{
sprint(ws_str_.s, "%d %d %g %g",\
granule_gid, mitral_gid, sm(), wm_normalized())
}
}else if (object_id(md2ampanmda)) {
sprint(ws_str_.s, "%d %d %g %g", mitral_gid, granule_gid, sg(), wg_normalized())
}else{
ws_str_.s = ""
}
return ws_str_
}
proc set_sm() {
if (object_id(gd2fi)) {
gd2fi.weight[1] = $1
gd2fi.weight[2] = gd2fi.weight[0]*fi.plast($1)
}
}
proc set_sg() {
if (object_id(md2ampanmda)){
md2ampanmda.weight[1] = $1
md2ampanmda.weight[2] = md2ampanmda.weight[0]*ampanmda.plast($1)
}
}
// Normalized weights
proc set_wm() { local val, max, min
if (object_id(gd2fi)) {
val = $1
max = 1.-(1./(1.+exp( 25./3.))) //fi.sighalf/fi.sigslope))
min = 1.-(1./(1.+exp(-25./3.))) //fi.sighalf/fi.sigslope))
if (val > max) {
val = max
}
if (val < min) {
val = min
}
gd2fi.weight[1] = fi.norm_weight_to_sig(val)
gd2fi.weight[2] = gd2fi.weight[0] * val
}
}
// Normalized weights
proc set_wg() { local val, max, min
if (object_id(md2ampanmda)){
val = $1
max = 1.-(1./(1.+exp( 25./3.))) //ampanmda.sighalf/fi.sigslope))
min = 1.-(1./(1.+exp(-25./3.))) //ampanmda.sighalf/fi.sigslope))
if (val > max) {
val = max
}
if (val < min) {
val = min
}
md2ampanmda.weight[1] = ampanmda.norm_weight_to_sig(val)
md2ampanmda.weight[2] = val //md2ampanmda.weight[0] * $1 // * ampanmda.gmax
}
}
func sm() {
return gd2fi.weight[1]
}
func sg() {
return md2ampanmda.weight[1]
}
func wm() {
return gd2fi.weight[2] * fi.gmax
}
func wg() {
return md2ampanmda.weight[2] * ampanmda.gmax
}
func wm_normalized() {
return gd2fi.weight[2]
}
func wg_normalized() {
return md2ampanmda.weight[2]
}
endtemplate MGRS
objref mgrs_list
mgrs_list = new List()
obfunc mk_mgrs() { local mitral_gid, granule_gid localobj mgrs
//$1 is the imitral, $s2 section name, $3 section arc position,
//$4 is the igranule, $s5 section name, $6 section arc position
mitral_gid = $1
granule_gid = $4 + num_granule_begin
if ($7 || exists(mitral_gid, $s2) || exists(granule_gid, $s5)) {
mgrs = new MGRS(mitral_gid, $s2, $3, granule_gid, $s5, $6, $7)
mgrs_list.append(mgrs)
return mgrs
}
return nil
}