TITLE HH KA anomalous rectifier channel
: Implemented in Rubin and Cleland (2006) J Neurophysiology
: Parameters from Bhalla and Bower (1993) J Neurophysiology
: Adapted from /usr/local/neuron/demo/release/khhchan.mod - squid
: by Andrew Davison, The Babraham Institute [Brain Res Bulletin, 2000]
NEURON {
SUFFIX kA
USEION k READ ek WRITE ik
RANGE gkbar, ik
GLOBAL pinf, qinf, ptau, qtau
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
v (mV)
dt (ms)
gkbar=.036 (mho/cm2) <0,1e9>
ek = -70 (mV)
}
STATE {
p q
}
ASSIGNED {
ik (mA/cm2)
pinf
qinf
ptau (ms)
qtau (ms)
}
INITIAL {
rates(v)
p = pinf
q = qinf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gkbar*p*q*(v - ek)
}
DERIVATIVE states {
rates(v)
p' = (pinf - p)/ptau
q' = (qinf - q)/qtau
}
PROCEDURE rates(v(mV)) {
TABLE pinf, qinf, ptau, qtau FROM -100 TO 100 WITH 200
ptau = 1.38(ms)
qtau = 150(ms)
pinf = 1/(1 + exp(-(v*1(/mV) + 42)/13))
qinf = 1/(1 + exp((v*1(/mV) + 110)/18))
}