TITLE Fast mechanism for submembranal Ca++ concentration (cai)
:
: Takes into account:
:
: - increase of cai due to calcium currents
: - extrusion of calcium with a simple first order equation
:
: This mechanism is compatible with the calcium pump "cad" and has the
: same name and parameters; however the parameters specific to the pump
: are dummy here.
:
: Parameters:
:
: - depth: depth of the shell just beneath the membran (in um)
: - cainf: equilibrium concentration of calcium (2e-4 mM)
: - taur: time constant of calcium extrusion (must be fast)
: - kt,kd: dummy parameters
:
: Written by Alain Destexhe, Salk Institute, 1995
: CONTRIBUTERS: Erica Griffith, Dec 2019; changing suffix to cadA1 (from cad) for use in A1 cortical model
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX cadA1
USEION ca READ ica, cai WRITE cai
RANGE depth,kt,kd,cainf,taur
}
UNITS {
(molar) = (1/liter) : moles do not appear in units
(mM) = (millimolar)
(um) = (micron)
(mA) = (milliamp)
(msM) = (ms mM)
}
CONSTANT {
FARADAY = 96489 (coul) : moles do not appear in units
: FARADAY = 96.489 (k-coul) : moles do not appear in units
}
PARAMETER {
depth = .1 (um) : depth of shell
taur = 5 (ms) : rate of calcium removal
cainf = 2e-4 (mM)
kt = 0 (mM/ms) : dummy
kd = 0 (mM) : dummy
}
STATE {
cai (mM)
}
INITIAL {
cai = cainf
}
ASSIGNED {
ica (mA/cm2)
drive_channel (mM/ms)
}
BREAKPOINT {
SOLVE state METHOD derivimplicit
}
DERIVATIVE state {
drive_channel = - (10000) * ica / (2 * FARADAY * depth)
if (drive_channel <= 0.) { drive_channel = 0. } : cannot pump inward
cai' = drive_channel + (cainf-cai)/taur
}