TITLE Calcium dependent potassium channel (small conductance SK)
UNITS {
(molar) = (1/liter)
(pA) = (picoamp)
(mV) = (millivolt)
(S) = (siemens)
(mA) = (milliamp)
(mM) = (millimolar)
}
:INDEPENDENT {v FROM -100 TO 50 WITH 50 (mV)}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX kca
USEION ca READ cai
USEION k WRITE ik
RANGE gkbar,km,oinf,n, ik,tausk, gk
}
PARAMETER {
dt (ms)
cai (mM)
celsius = 35 (degC)
gkbar = 59.00e-6 (S/cm2)
ek = -90.0 (mV)
km = 0.00019 (mM)
n = 4.0 (1)
tausk = 4.0 (ms)
}
ASSIGNED {
ik (mA/cm2)
gk (S/cm2)
oinf
}
STATE {
m
}
BREAKPOINT {
SOLVE states METHOD cnexp
:oinf = 1/(1 + pow(km/caski,n))
oinf = 1/(1 + pow(km/cai,n))
gk = m*gkbar
ik = gk*(v - ek)
:ik = oinf*gkbar*(v - ek)
}
INITIAL {
m = 1/(1 + pow(km/cai,n))
}
DERIVATIVE states {
LOCAL minf
:minf = 1/(1 + pow(km/caski,n))
minf = 1/(1 + pow(km/cai,n))
m' = (minf-m)/tausk
}