TITLE K slow channel from Wang (2002)
: M.Migliore Dec. 2003
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
celsius (degC)
gksbar=.005 (mho/cm2)
q10=2
ek
:vhalfp=-34
vhalfp=-35
:tp=10
tp=6
:kp=6.5
kp=2
:vhalfq =-65
vhalfq=-50
kq =6.6
:to =200
to=10
tk =6.85 :6.8
:a0q=220
a0q=100
:tvh=-71.6
tvh=-50
}
NEURON {
SUFFIX ks
USEION k READ ek WRITE ik
RANGE gksbar,gks
GLOBAL pinf,qinf,taup,tauq
}
STATE {
p
q
}
ASSIGNED {
ik (mA/cm2)
pinf
qinf
taup
tauq
gks
}
INITIAL {
rates(v)
p=pinf
q=qinf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gks = gksbar*p*q
ik = gks*(v-ek)
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rates(v)
p' = (pinf - p)/taup
q' = (qinf - q)/tauq
}
PROCEDURE rates(v (mV)) { :callable from hoc
LOCAL qt
qt=q10^((celsius-25)/10)
pinf = (1/(1+ exp(-(v-vhalfp)/kp)))
qinf = (1/(1+ exp((v-vhalfq)/kq)))
taup = tp/qt
tauq = to + a0q/(1+exp(-(v-tvh)/tk))/qt
}