/************************************************************
'ca1' model code repository
Written by Marianne Bezaire, marianne.bezaire@gmail.com, www.mariannebezaire.com
In the lab of Ivan Soltesz, www.ivansolteszlab.org
Latest versions of this code are available online at:
ModelDB:
Open Source Brain: http://www.opensourcebrain.org/projects/nc_ca1
Main code file: ../main.hoc
This file: Last updated on April 9, 2015
This file creates the instances of the CellCategoryInfo template, one
for each cell type, and loads in the information about each cell type
into each object.
It adjusts the number of each cell type based on the Scale parameter
of the model and also whether any cells are subject to cell death (for
modeling injuries to the network).
It reads in a particular cellnumbers dataset as specified in the
parameters:
./datasets/cellnumbers_###.dat where ### is the parameter NumData
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objref f2 // Define object reference for the cellnumbers file
objref celltypestring[1], techstring[1], cellType[1] // Define placeholder objects with a size of one, then
// redefine them with the correct size in the proc
double cellnumvar[1], cellLayerflag[1], cellArtflag[1], numCellTypes[1] // Define placeholder doubles with a size
// of one, then redefine them with the
// correct size in the proc
objref pnmtmp, pctmp, nil
proc loadCellCategoryInfo() {local i, startpos // This function will load celltype info into a CellCategoryInfo
// object (one object per cell type)
f2 = new File()
sprint(cmdstr, "../datasets/cellnumbers_%g.dat", NumData) // Open the NumData dataset specified by the user (a
f2.ropen(cmdstr) // 3-digit number), which gives the number of cell
// types in the model, followed by one line for each
// cell type, which gives information about the type,
// number of cells, layer in which they are found, etc.
numCellTypes = f2.scanvar // Scan the first line, which contains a number giving the # of cell types
// Define variables to temporarily hold data scanned from file
objref celltypestring[numCellTypes], techstring[numCellTypes], cellType[numCellTypes]
double cellnumvar[numCellTypes], cellLayerflag[numCellTypes], cellArtflag[numCellTypes]
for i=0, numCellTypes-1 { // For each cell type in the model
celltypestring[i]= new String()
techstring[i] = new String()
f2.scanstr(celltypestring[i].s) // Scan in the friendly cell name
f2.scanstr(techstring[i].s) // Scan in the technical cell name
cellnumvar[i]=f2.scanvar // Scan in the number of each cell type
cellLayerflag[i]=f2.scanvar // Scan the layer index (layers are defined by the user in the
// LayerHeights parameter)
cellArtflag[i]=f2.scanvar // Scan in artificial flag, 1 = artificial cell, 0 = real cell
cellnumvar[i]=int(cellnumvar[i]/Scale + .5) // Scale down the number of cells in the model based on the Scale parameter
// The 'if' condition below is where cells are flagged for cell death, as mentioned in the comments for the
// PercentCellDeath parameter in the parameters.hoc file
if (cellLayerflag[i]==0) { // For cell types in a certain layer (in this example, layer index 0) are
// susceptible to death (because you are modeling an injury, for example)
// then use the PercentCellDeath parameter to calculate how many cells should
// survive.
cellnumvar[i] = int(cellnumvar[i] * ((100-PercentCellDeath)/100))
}
if (cellnumvar[i]<1) {
cellnumvar[i]=1 // If all cells of a type are killed or
// if the number of cells is scaled down
// to less than 1, ensure there is one
// cell of that type in the model.
}
}
f2.close() // Close the cellnumbers dataset file
startpos=0 // Start the gid range at 0
for i=0, numCellTypes-1 {
cellType[i] = new CellCategoryInfo(i) // Make one object for each cell type to store the info for that cell type
// Set the properties of that cell type (the properties that were read in from the cellnumbers dataset file)
cellType[i].setCellTypeParams(celltypestring[i].s, techstring[i].s, startpos, cellnumvar[i], cellLayerflag[i], cellArtflag[i])
// Initialize a placeholder vector that will store information about connectivity from other cell types to this cell type
cellType[i].numCons = new Vector(numCellTypes,0)
cellType[i].setCellTypeDist // Load the axonal distribution file
startpos = startpos + cellnumvar[i] // Increment the startGid for the next cell type's call to setCellTypeParams
}
}
loadCellCategoryInfo()