:Comment :
:Reference : : Reuveni, Friedman, Amitai, and Gutnick, J.Neurosci. 1993
NEURON {
SUFFIX Ca_HVA_hay
USEION ca READ eca WRITE ica
RANGE gCa_HVAbar, gCa_HVA, ica, offma, offmb, offha, offhb, sloma, slomb, sloha, slohb, tauma, taumb, tauha, tauhb
}
UNITS {
(S) = (siemens)
(mV) = (millivolt)
(mA) = (milliamp)
}
PARAMETER {
gCa_HVAbar = 0.00001 (S/cm2)
offma = -27 (mV)
offmb = -75 (mV)
offha = -13 (mV)
offhb = -15 (mV)
sloma = 3.8 (mV)
slomb = 17 (mV)
sloha = 50 (mV)
slohb = 28 (mV)
tauma = 18.1818 (ms)
taumb = 1.06383 (ms)
tauha = 2188.18 (ms)
tauhb = 153.846 (ms)
}
ASSIGNED {
v (mV)
eca (mV)
ica (mA/cm2)
gCa_HVA (S/cm2)
mInf
mTau
mAlpha
mBeta
hInf
hTau
hAlpha
hBeta
}
STATE {
m
h
}
BREAKPOINT {
SOLVE states METHOD cnexp
gCa_HVA = gCa_HVAbar*m*m*h
ica = gCa_HVA*(v-eca)
}
DERIVATIVE states {
rates()
m' = (mInf-m)/mTau
h' = (hInf-h)/hTau
}
INITIAL{
rates()
m = mInf
h = hInf
}
PROCEDURE rates(){
UNITSOFF
if((v == offma) ){
v = v+0.0001
}
mAlpha = (offma-v)/tauma/(exp((offma-v)/sloma) - 1)
mBeta = exp((offmb-v)/slomb)/taumb
mInf = mAlpha/(mAlpha + mBeta)
mTau = 1/(mAlpha + mBeta)
hAlpha = exp((offha-v)/sloha)/tauha
hBeta = 1.0/tauhb/(exp((offhb-v)/slohb)+1)
hInf = hAlpha/(hAlpha + hBeta)
hTau = 1/(hAlpha + hBeta)
UNITSON
}