TITLE hyperpolarization-activated current (H-current)
COMMENT
Based on Williams and Stuart J. Neurophysiol 83:3177,2000
ENDCOMMENT
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX iHalmog
USEION h READ eh WRITE ih VALENCE 1
RANGE gbar, h_inf, tau, ih, t0,t1,off, slo, offt1, offt2, slot1, slot2, q10, temp, tadj, vmin,vmax
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(molar) = (1/liter)
(mM) = (millimolar)
(pS) = (picosiemens)
(um) = (micron)
}
PARAMETER {
v (mV)
celsius (degC)
eh (mV)
gbar = 0.0 (pS/um2)
off = -91 (mV) : V1/2 of activation
slo=6 (mV) : slope of activation
t0 = 2542.5883549 (ms) : parameters for time constant of activation
t1 = 11.40250855 (ms)
offt1 = 0 (mV)
offt2 = 0 (mV)
slot1 = 40.1606426 (mV)
slot2 = 16.1290323 (mV)
temp = 21 (degC) : original temp
q10 = 2.3 : temperature sensitivity
vmin = -120 (mV)
vmax = 100 (mV)
}
ASSIGNED {
ih (mA/cm2)
h_inf
tau (ms)
tadj
}
STATE { h }
INITIAL {
rates(v)
h = h_inf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ih = (1e-4) * gbar * h * (v-eh)
}
DERIVATIVE states {
rates(v)
h' = (h_inf-h)/tau
}
PROCEDURE rates( v (mV)) {
tadj= q10^((celsius-22)/10)
h_inf = 1/(1+exp((v-off)/slo))
tau = 1/(tadj*(exp(-(v-offt1)/slot1)/t0+exp((v-offt2)/slot2)/t1))
}