TITLE KA
: K-A current for motoneuron from Safronov and Vogel (1995).
: M.Migliore Dec. 2001
NEURON {
SUFFIX kamot
USEION k READ ek WRITE ik
RANGE gbar
GLOBAL minf, mtau, hinf, htau
}
PARAMETER {
gbar = 0.02 (mho/cm2)
celsius
ek (mV) : must be explicitly def. in hoc
v (mV)
a0m=0.085
vhalfm=-75
zetam=2
gmm=0.7
mmin=0.1
a0h=0.008
vhalfh=-85.8
zetah=3
gmh=0.75
hmin=0.1
q10=3
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
}
ASSIGNED {
ik (mA/cm2)
minf mtau (ms)
hinf htau (ms)
}
STATE { m h}
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gbar*m*h* (v - ek)
}
INITIAL {
trates(v)
m=minf
h=hinf
}
DERIVATIVE states {
trates(v)
m' = (minf-m)/mtau
h' = (hinf-h)/htau
}
PROCEDURE trates(v) {
LOCAL qt
qt=q10^((celsius-22)/10)
minf = 1/(1 + exp(-(v+36.2)/9.1))
mtau = betm(v)/(qt*a0m*(1+alpm(v)))
if (mtau<mmin/qt) {mtau=mmin/qt}
hinf = 1/(1 + exp((v+85.8)/13.2))
htau = beth(v)/(qt*a0h*(1+alph(v)))
if (htau<hmin/qt) {htau=hmin/qt}
}
FUNCTION alpm(v(mV)) {
alpm = exp(1.e-3*zetam*(v-vhalfm)*9.648e4/(8.315*(273.16+celsius)))
}
FUNCTION betm(v(mV)) {
betm = exp(1.e-3*zetam*gmm*(v-vhalfm)*9.648e4/(8.315*(273.16+celsius)))
}
FUNCTION alph(v(mV)) {
alph = exp(1.e-3*zetah*(v-vhalfh)*9.648e4/(8.315*(273.16+celsius)))
}
FUNCTION beth(v(mV)) {
beth = exp(1.e-3*zetah*gmh*(v-vhalfh)*9.648e4/(8.315*(273.16+celsius)))
}