TITLE na3
: Na current for Retinal Ganglion Cell from Benison et al (2001)
: M.Migliore Nov. 2001
NEURON {
SUFFIX nargc
USEION na READ ena WRITE ina
RANGE gbar
GLOBAL minf, hinf, mtau, htau
}
PARAMETER {
gbar = 0.010 (mho/cm2)
ena (mV) : must be explicitly def. in hoc
celsius
v (mV)
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
}
ASSIGNED {
ina (mA/cm2)
minf hinf
mtau (ms) htau (ms)
}
STATE { m h}
BREAKPOINT {
SOLVE states METHOD cnexp
ina = gbar*m*m*m*h * (v - ena)
}
INITIAL {
trates(v)
m=minf
h=hinf
}
DERIVATIVE states {
trates(v)
m' = (minf-m)/mtau
h' = (hinf-h)/htau
}
PROCEDURE trates(vm) {
LOCAL a, b
a = trap0(vm,-29,0.5,0.18)
b = 6*exp(-(vm+45)/15)
minf = a/(a+b)
mtau = 1/(a+b)
a = 0.15*exp(-(vm+47)/20)
b = 2.8/(1+exp(-0.1*(vm+20)))
hinf = a/(a+b)
htau = 1/(a+b)
}
FUNCTION trap0(v,th,a,q) {
if (fabs(v-th) > 1e-6) {
trap0 = a * (v - th) / (1 - exp(-(v - th)*q))
} else {
trap0 = a / q
}
}